Harris M, Vasudev K S, Anfield C, Wells S
Histopathology. 1978 May;2(3):177-88. doi: 10.1111/j.1365-2559.1978.tb01708.x.
The ultrastructural characteristics of mucin production in mammary mucoid carcinoma, signet ring cell carcinoma (Harris, Wells & Vasudev 1978), papillary carcinoma and lobular carcinoma are compared. The mucin in lobular carcinoma is confined to intracytoplasmic lumina whereas it is present as membrane bound granules in the other three types, although intracytoplasmic lumina also occur in the latter. A possible origin of intracytoplasmic lumina from distended Golgi cisternae is proposed. Possibly, extracellular mucin acts as a mechanical barrier between tumour cells and lymphatics, thus explaining the good prognosis of typical mucoid carcinomas.
对乳腺黏液癌、印戒细胞癌（哈里斯、韦尔斯和瓦苏德夫，1978年）、乳头状癌和小叶癌中黏蛋白产生的超微结构特征进行了比较。小叶癌中的黏蛋白局限于胞质内陷窝，而在其他三种类型中则以膜结合颗粒的形式存在，尽管后三种类型中也会出现胞质内陷窝。有人提出胞质内陷窝可能起源于扩张的高尔基体池。细胞外黏蛋白可能在肿瘤细胞和淋巴管之间起到机械屏障的作用，从而解释了典型黏液癌的良好预后。
