Ferguson D J, Anderson T J, Wells C A, Battersby S
Histopathology. 1986 Dec;10(12):1219-30. doi: 10.1111/j.1365-2559.1986.tb02566.x.
The ultrastructural characteristics of 14 cases of mucoid carcinoma of the breast, with different histological appearances, have been examined. Thirteen of the tumours were observed to consist of two populations of tumour cells, one showing secretory changes while the other group showed no evidence of activity. In one tumour only synthetically active cells were observed. Ultrastructurally, six different types of cytoplasmic granules, comprising typical mucin plus glycoprotein or protein-containing granules, were identified within the synthetically active tumour cells. The number of types of granules and the relative proportion of the various granules varied between tumours with only mucin granules present in all tumours. It would appear that synthetic pathways are activated in certain tumours which result in protein/glycoprotein granules associated with the argyrophilia observed histologically. In addition, the tumours varied with respect to luminal differentiation, presence of intracytoplasmic lumina, intracytoplasmic mucin pools, lipid droplets, ciliated cells and areas of calcification. The marked heterogeneity of the ultrastructural features of the mucoid carcinoma of the breast prevents the tumours from being readily divided into distinct subgroups.
对14例具有不同组织学表现的乳腺黏液癌的超微结构特征进行了检查。观察到其中13个肿瘤由两类肿瘤细胞组成，一类显示分泌变化，而另一组未显示活动迹象。在一个肿瘤中仅观察到具有合成活性的细胞。在超微结构上，在具有合成活性的肿瘤细胞内鉴定出六种不同类型的细胞质颗粒，包括典型的粘蛋白加上糖蛋白或含蛋白质的颗粒。颗粒类型的数量和各种颗粒的相对比例在肿瘤之间有所不同，所有肿瘤中均存在粘蛋白颗粒。似乎在某些肿瘤中合成途径被激活，这导致了组织学上观察到的与嗜银性相关的蛋白质/糖蛋白颗粒。此外，肿瘤在管腔分化、胞质内管腔的存在、胞质内粘蛋白池、脂滴、纤毛细胞和钙化区域方面存在差异。乳腺黏液癌超微结构特征的显著异质性使得这些肿瘤难以轻易地分为不同的亚组。
