Boldt H C, Folk J C
Department of Ophthalmology, University of Iowa, Iowa City.
Retina. 1990;10(4):244-50. doi: 10.1097/00006982-199010000-00003.
The authors describe a condition called retinal pigment epithelial (RPE) ooze in patients with age-related macular degeneration. Patients with ooze have a neurosensory retinal detachment, a slowly progressive indiscrete leakage of fluorescein dye from the level of the retinal pigment epithelium, and no other signs of choroidal neovascularization. Sixteen patients with RPE ooze were followed for a mean of 4.5 years without treatment. Nine patients had a single round or oval area of leakage. In seven of these patients, choroidal neovascular membranes developed, with moderate to poor visual outcomes. The other seven patients had multiple smaller areas of leakage from the level of the RPE. None of these patients had a choroidal neovascular membrane, and all had resolution of the subretinal fluid with good final visual acuities. Patients with discrete round or oval RPE oozes appear to be at a high risk for the development of more definite choroidal neovascular membranes and vision loss.
作者描述了一种在年龄相关性黄斑变性患者中出现的称为视网膜色素上皮（RPE）渗漏的情况。有渗漏的患者存在神经感觉性视网膜脱离，荧光素染料从视网膜色素上皮水平缓慢进行性地弥散性渗漏，且无脉络膜新生血管的其他体征。16例RPE渗漏患者未经治疗平均随访4.5年。9例患者有单个圆形或椭圆形渗漏区。其中7例患者出现脉络膜新生血管膜，视力预后为中度至较差。另外7例患者在RPE水平有多个较小的渗漏区。这些患者均无脉络膜新生血管膜，所有患者视网膜下液均消退，最终视力良好。有离散圆形或椭圆形RPE渗漏的患者似乎发生更明确的脉络膜新生血管膜和视力丧失的风险很高。
