作为潜在抗菌剂的3-(1,3,4-噻二唑-2-基)吡唑并[1,5-a]嘧啶衍生物的合成
Synthesis of 3-(1,3,4-thiadiazol-2-yl)pyrazolo[1,5-a] pyrimidine derivatives as potential antimicrobial agents.
作者信息
Auzzi G, Costanzo A, Bruni F, Clauser M, Guerrini G, Selleri S, Pecori Vettori L
机构信息
Dipartimento di Scienze Farmaceutiche, Università Degli Studi di Firenze, Italy.
出版信息
Farmaco. 1990 Nov;45(11):1193-205.
PMID:2128451
Abstract
The synthesis of some 3-(1,3,4-thiadiazol-2-yl)pyrazolo[1,5-a]-pyrimidine derivatives is performed by reacting 2-(3-amino-1,2-dihydro-5-oxo-5H-pyrazol-4-il)-1,3,4- thiadiazoles with 2,4-pentanedione, ethyl 3-oxobutyrate and diethyl ethoxymethylenemalonate. The antimicrobial activity of the synthesized compounds is reported.
摘要
通过使2-(3-氨基-1,2-二氢-5-氧代-5H-吡唑-4-基)-1,3,4-噻二唑与2,4-戊二酮、3-氧代丁酸乙酯和乙氧基甲叉丙二酸二乙酯反应来合成一些3-(1,3,4-噻二唑-2-基)吡唑并[1,5-a]嘧啶衍生物。报道了所合成化合物的抗菌活性。
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