Beuth J, Ko H L, Roszkowski W, Roszkowski K, Ohshima Y
Institute of Medical Microbiology and Hygiene, University of Cologne.
Zentralbl Bakteriol. 1990 Dec;274(3):350-8. doi: 10.1016/s0934-8840(11)80692-4.
Adhesion of bacteria and adhesion of tumor cells have much in common, especially the participation of lectins in this process. In the future it might be possible to inhibit the metastatic process into the liver (e.g. during surgical operations of malignant tumors) and bacterial adherence to mucosal linings or plastic devices by blocking of adhesion molecules (lectins) with appropriate glycoconjugates. Initial clinical trials are very promising.
细菌的黏附和肿瘤细胞的黏附具有许多共同之处，尤其是凝集素在这一过程中的参与。未来或许有可能通过用合适的糖缀合物阻断黏附分子（凝集素）来抑制肿瘤细胞向肝脏的转移过程（例如在恶性肿瘤的外科手术期间）以及细菌对黏膜内衬或塑料装置的黏附。初步临床试验前景十分广阔。
