过去硫胺素缺乏会降低对乙醇的反应。

Response to ethanol reduced by past thiamine deficiency.

作者信息

Martin P R, Majchrowicz E, Tamborska E, Marietta C, Mukherjee A B, Eckardt M J

出版信息

Science. 1985 Mar 15;227(4692):1365-8. doi: 10.1126/science.3975622.

Abstract

Ethanol-induced intoxication and hypothermia were studied in rats approximately 7 months after severe thiamine deficiency, when treated rats appeared to have recovered their physical health. Previously induced thiamine deficiency without prior ethanol exposure significantly decreased the area under the curve plotted for the concentration of ethanol in blood and also decreased behavioral impairment and hypothermia due to ethanol exposure. Pathophysiologic changes resulting from thiamine deficiency may contribute to both the pharmacodynamic and pharmacokinetic tolerance to ethanol in chronic alcoholics.

摘要

在严重硫胺素缺乏约7个月后的大鼠中研究了乙醇诱导的中毒和体温过低情况，此时经治疗的大鼠似乎已恢复身体健康。先前诱导的硫胺素缺乏且未事先接触乙醇，显著降低了血液中乙醇浓度曲线下的面积，也减轻了因接触乙醇导致的行为损伤和体温过低。硫胺素缺乏引起的病理生理变化可能导致慢性酗酒者对乙醇产生药效学和药代动力学耐受性。