Eisen M, Motum P, Gibson J, Uhr E, Gett M, Kronenberg H, Wylie B
N.S.W. Red Cross Blood Transfusion Service, Royal Prince Alfred Hospital, Sydney.
Pathology. 1990 Oct;22(4):203-5. doi: 10.3109/00313029009086663.
A 31 year old woman was assessed following delivery of her second child affected by neonatal alloimmune thrombocytopenia (NAIT). Antiplatelet antibodies with specificity for Bak(a) were identified in the woman's serum and her platelets were typed as Bak(a) negative whilst her husband's were Bak(a) positive. Unlike the majority of reported anti-Bak(a) antibodies in the literature, this patient's serum contained no contaminating anti-HLA antibodies. This is the first report of NAIT caused by an anti-Bak(a) without co-existing anti-HLA antibodies. An anti-Bak(a) antibody has not previously been reported in Australia. The current status of this antigen system is reviewed.
一名31岁女性在其第二个孩子患新生儿同种免疫性血小板减少症（NAIT）后接受了评估。在该女性血清中鉴定出对Bak(a)具有特异性的抗血小板抗体，其血小板分型为Bak(a)阴性，而其丈夫的血小板为Bak(a)阳性。与文献中报道的大多数抗Bak(a)抗体不同，该患者血清中未含有污染性抗HLA抗体。这是首例由无共存抗HLA抗体的抗Bak(a)引起的NAIT报告。此前澳大利亚尚未报道过抗Bak(a)抗体。本文对该抗原系统的现状进行了综述。
