Keighley G, Cohen N S
J Med. 1978;9(2):129-38.
Adenosine 3',5'-monophosphate, 2 to 16 mg, and prostaglandin E1, 0.05 to 0.10 mg, stimulate erythropoiesis in ex-hypoxic, polycythemic mice. The stimulation can be prevented by the simultaneous administration of an antiserum to erythropoietin. India ink penetration shows that at these doses blood circulation is blocked in the kidney. Tissue hypoxia, especially in the kidney, causes production of erythropietin. The strong effect on the kidney circulation suggests that the major part of the stimulation of erythropoiesis by these agents is through their effect on renal circulation.
3',5'-单磷酸腺苷2至16毫克和前列腺素E1 0.05至0.10毫克可刺激低氧后红细胞增多症小鼠的红细胞生成。同时给予促红细胞生成素抗血清可阻止这种刺激。印度墨汁渗透显示，在这些剂量下，肾脏中的血液循环受阻。组织缺氧，尤其是肾脏中的缺氧，会导致促红细胞生成素的产生。对肾脏循环的强烈影响表明，这些药物对红细胞生成的刺激作用主要是通过它们对肾脏循环的影响实现的。
