Morshchakova E F
Gematol Transfuziol. 1990 Jul;35(7):23-5.
Participation of cAMP, cGMP and certain classes of prostaglandins (PG) in the mechanisms of erythropoietin production by the kidneys, and in the reactions of erythropoietin-sensitive bone marrow cells in response to the hormone, was studied. It has been shown that cAMP, PGA2, PGE1 and PGI2 stimulate erythropoietin production under physiologic conditions as well as produce modulating effect on hormone synthesis under the action of hypoxia. The role of cyclic nucleotides and PG as messengers from erythropoietin to genome++ of erythropoietin-sensitive cells has been considered.
研究了环磷酸腺苷（cAMP）、环磷酸鸟苷（cGMP）和某些类别的前列腺素（PG）在肾脏产生促红细胞生成素的机制中，以及在促红细胞生成素敏感的骨髓细胞对该激素反应中的参与情况。结果表明，cAMP、前列环酸（PGA2）、前列腺素E1（PGE1）和前列环素（PGI2）在生理条件下刺激促红细胞生成素的产生，并且在缺氧作用下对激素合成产生调节作用。还探讨了环核苷酸和PG作为从促红细胞生成素到促红细胞生成素敏感细胞基因组的信使的作用。
