[The role of cyclic nucleotides and prostaglandins in the regulation of erythropoiesis].

Participation of cAMP, cGMP and certain classes of prostaglandins (PG) in the mechanisms of erythropoietin production by the kidneys, and in the reactions of erythropoietin-sensitive bone marrow cells in response to the hormone, was studied. It has been shown that cAMP, PGA2, PGE1 and PGI2 stimulate erythropoietin production under physiologic conditions as well as produce modulating effect on hormone synthesis under the action of hypoxia. The role of cyclic nucleotides and PG as messengers from erythropoietin to genome++ of erythropoietin-sensitive cells has been considered.