Morace G, Tamburrini E, Manzara S, Antinori A, Maiuro G, Dettori G
Istituto di Microbiologia, Facoltà di Medicina e Chirurgia A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
Eur J Epidemiol. 1990 Dec;6(4):398-403. doi: 10.1007/BF00151714.
Mycological, cultural and/or serological studies were performed on 98 patients hospitalized in the Department of Infectious Diseases of the Catholic University in Rome with diagnoses of acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC) diseases. The incidence of mycoses was evaluated by retrospectively analyzing the results of mycological examinations and comparing them with clinical manifestations. The presence of concomitant bacterial, viral and parasitic infections was also examined. For epidemiological purposes, the study was extended to include the biotyping of all yeasts isolated from patients hospitalized between September 1988 and February 1989 in the same Department. Antimycotic susceptibility was also determined for the first yeast isolate obtained from each of these patients. Oral candidiasis (50 cases) caused by Candida albicans was the most frequent mycosis, followed by esophageal candidiasis (13 cases) and cryptococcosis (6 cases). Four out of the 6 cryptococcosis patients had meningeal involvement. Systemic candidiasis (2 cases) and aspergillosis (1 case) were less common. Biotyping of yeasts isolated between September 1988 and February 1989 with the killer system revealed type 377 to be the most common among the C. albicans isolates. It represented 70% of all the yeasts isolated.
对罗马天主教大学传染病科收治的98例诊断为获得性免疫缺陷综合征（AIDS）或AIDS相关综合征（ARC）疾病的患者进行了真菌学、培养和/或血清学研究。通过回顾性分析真菌学检查结果并将其与临床表现进行比较，评估了真菌病的发病率。还检查了是否存在合并细菌、病毒和寄生虫感染。出于流行病学目的，该研究扩展至对1988年9月至1989年2月在同一科室住院患者分离出的所有酵母进行生物分型。还对从这些患者中分离出的第一株酵母测定了抗真菌药敏性。由白色念珠菌引起的口腔念珠菌病（50例）是最常见的真菌病，其次是食管念珠菌病（13例）和隐球菌病（6例）。6例隐球菌病患者中有4例累及脑膜。系统性念珠菌病（2例）和曲霉病（1例）较少见。用杀伤系统对1988年9月至1989年2月分离出的酵母进行生物分型显示，377型在白色念珠菌分离株中最为常见。它占所有分离出酵母的70%。
