Soriano Maria Eugenia, Scorrano Luca
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Padova, Italy.
Adv Exp Med Biol. 2010;687:97-114. doi: 10.1007/978-1-4419-6706-0_6.
Apoptosis is a highly regulated process where key players such as BCL-2 family members control the recruitment of the mitochondrial subroutine. This culminates in the release of cytochrome c from the organelle in the cytoplasm, where it is required for the activation of effector caspases. The complete release of cytochrome c is the result of the combined action of proapoptotic BCL-2 family members and of changes in the complex morphology and ultrastructure of the organelle, controlled by the balance between fusion and fission processes. Here we discuss recent findings pointing to a role for changes in mitochondrial morphology during apoptosis and how these might be regulated by members of the BCL-2 family.
细胞凋亡是一个高度调控的过程，其中诸如BCL-2家族成员等关键因子控制着线粒体亚程序的募集。这最终导致细胞色素c从细胞器释放到细胞质中，而效应半胱天冬酶的激活需要细胞色素c。细胞色素c的完全释放是促凋亡BCL-2家族成员共同作用以及细胞器复杂形态和超微结构变化的结果，这些变化由融合和裂变过程之间的平衡控制。在这里，我们讨论了最近的研究结果，这些结果指出了细胞凋亡期间线粒体形态变化的作用，以及BCL-2家族成员可能如何对其进行调控。
