Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, USA.
Adv Exp Med Biol. 2010;688:24-45. doi: 10.1007/978-1-4419-6741-1_2.
Sphingolipids are a family of ubiquitous membrane components that exhibit multiple functional properties fundamental to cell properties. Sphingolipid transport represents a crucial aspect in the metabolism, signaling and biological role of sphingolipids. Different mechanisms of sphingolipid movements contribute to their selective localization in different membranes but also in different portions and sides of the same membrane, thus ensuring and regulating their interaction with different enzymes and target molecules. In this chapter we will describe the knowledge of the different mechanisms ofsphingolipid movements within and between membranes, focusing on the recent advances in this field and considering the role played by selective sphingolipid molecules in the regulation of these mechanisms.
鞘脂是一类普遍存在于细胞膜中的成分，具有多种对细胞特性至关重要的功能特性。鞘脂的转运是其代谢、信号转导和生物学作用的关键方面。鞘脂运动的不同机制有助于它们在不同的膜中以及同一膜的不同部分和侧面进行选择性定位，从而确保并调节它们与不同的酶和靶分子的相互作用。在本章中，我们将描述鞘脂在膜内外运动的不同机制的知识，重点介绍该领域的最新进展，并考虑选择性鞘脂分子在调节这些机制中所起的作用。
