Departments of 1Rheumatology.
Scand J Rheumatol. 2011 Jan;40(1):68-73. doi: 10.3109/03009742.2010.500618. Epub 2010 Oct 5.
To investigate factors associated with absence of osteoarthritis (OA).
In 82 well-functioning 90-year-old participants from a cross-sectional birth cohort, radiographs of hands, hips, and knees were acquired and scored according to the Kellgren and Lawrence (K-L) method for determining OA. A score of ≥ 2 was considered as OA. 'Free from OA' was defined as no hip or knee OA and less than three hand joints with OA. Logistic regression analyses were used to investigate associations with absence of OA.
Absence of hip, knee, and hand OA was seen in 63, 51, and 29% of participants, respectively. Joints on the left and right side of the body were equally affected. Sixteen per cent of 90-year old participants were 'free from OA'. Absence of knee OA was associated with being male. A family history of finger nodes was negatively associated with absence of hip and hand OA. Body mass index (BMI) was negatively associated with 'free from OA', and also with absence of hip and knee OA. A history of heavy occupational work was associated with 'free from OA' [odds ratio (OR) 7.2, 95% confidence interval (CI) 1.3-39.9] and with absence of hand OA in particular (OR 2.7, 95% CI 1.0-7.1).
In 90-year-olds, absence of OA is associated with male sex, a normal BMI, absence of familial predisposition for OA, and, contrary to our expectation, heavy work. Further research in protective genetic factors is needed.
探讨与骨关节炎（OA）缺失相关的因素。
在一项横断面出生队列中，对 82 名功能良好的 90 岁参与者进行手部、臀部和膝关节的 X 光检查，并根据 Kellgren 和 Lawrence（K-L）方法对其进行评分，以确定 OA。评分≥2 被认为是 OA。“无 OA”定义为无髋或膝 OA，且手部少于三个关节有 OA。采用 logistic 回归分析探讨与 OA 缺失相关的因素。
分别有 63%、51%和 29%的参与者无髋、膝和手 OA。身体左右两侧的关节受影响程度相同。16%的 90 岁参与者“无 OA”。无膝 OA 与男性有关。手指节点家族史与髋和手 OA 的缺失呈负相关。体质指数（BMI）与“无 OA”呈负相关，与髋和膝 OA 的缺失也呈负相关。职业性体力劳动史与“无 OA”相关（比值比[OR]7.2，95%置信区间[CI]1.3-39.9），与手部 OA 的缺失尤其相关（OR 2.7，95% CI 1.0-7.1）。
在 90 岁人群中，OA 的缺失与男性、正常 BMI、OA 的家族易感性缺失以及与我们的预期相反的重体力劳动有关。需要进一步研究保护性遗传因素。
