Department of Pediatrics, Herman B Wells Center for Pediatric Research, Walnut, Indianapolis 46202, USA.
Cancer Invest. 2010 Nov;28(9):885-95. doi: 10.3109/07357907.2010.512816.
Pancreatic cancer is a deadly disease that is virtually never cured. Understanding the chemoresistance intrinsic to this cancer will aid in developing new regimens. High expression of APE1/Ref-1, a DNA repair and redox signaling protein, is associated with resistance, poor outcome, and angiogenesis; little is known in pancreatic cancer. Immunostaining of adenocarcinoma shows greater APE1/Ref-1 expression than in normal pancreas tissue. A decrease in APE1/Ref-1 protein levels results in pancreatic cancer cell growth inhibition, increased apoptosis, and altered cell cycle progression. Endogenous cell cycle inhibitors increase when APE1/ Ref-1 is reduced, demonstrating its importance to proliferation and growth of pancreatic cancer.
胰腺癌是一种致命的疾病，几乎从未被治愈过。了解这种癌症固有的化疗耐药性将有助于开发新的治疗方案。高水平表达 APE1/Ref-1，一种 DNA 修复和氧化还原信号蛋白，与耐药性、不良预后和血管生成有关；在胰腺癌中知之甚少。腺癌的免疫染色显示 APE1/Ref-1 的表达高于正常胰腺组织。APE1/Ref-1 蛋白水平的降低导致胰腺癌细胞生长抑制、凋亡增加和细胞周期进程改变。当 APE1/Ref-1 减少时，内源性细胞周期抑制剂增加，表明其对胰腺癌的增殖和生长很重要。
