开发一种实用的指南，用于早期识别足部和趾甲恶性黑色素瘤。
Development of a practical guide for the early recognition for malignant melanoma of the foot and nail unit.
机构信息
School of Health Sciences, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.
出版信息
J Foot Ankle Res. 2010 Sep 28;3:22. doi: 10.1186/1757-1146-3-22.
BACKGROUND
Malignant melanoma is a rare but potentially lethal form of cancer which may arise on the foot. Evidence suggests that due to misdiagnosis and later recognition, foot melanoma has a poorer prognosis than cutaneous melanoma elsewhere.
METHODS
A panel of experts representing podiatry and dermatologists with a special interest in skin oncology was assembled to review the literature and clinical evidence to develop a clinical guide for the early recognition of plantar and nail unit melanoma.
RESULTS
A systematic review of the literature revealed little high quality data to inform the guide. However a significant number of case reports and series were available for analysis. From these, the salient features were collated and summarised into the guide. Based on these features a new acronym "CUBED" for foot melanoma was drafted and incorporated in the guide.
CONCLUSIONS
The use of this guide may help clinicians in their assessment of suspicious lesions on the foot (including the nail unit). Earlier detection of suspicious pedal lesions may facilitate earlier referral for expert assessment and definitive diagnosis. The guide is currently being field tested amongst practitioners.
背景
恶性黑色素瘤是一种罕见但潜在致命的癌症形式，可能发生在足部。有证据表明，由于误诊和后期诊断，足部黑色素瘤的预后比其他部位的皮肤黑色素瘤差。
方法
一个由足病医生和皮肤科医生组成的专家组，他们对皮肤肿瘤学有特殊兴趣，被召集起来审查文献和临床证据，以制定一个用于早期识别足底和甲单元黑色素瘤的临床指南。
结果
对文献的系统回顾显示，几乎没有高质量的数据来为该指南提供信息。然而，有大量的病例报告和系列可供分析。从这些报告中，收集和总结了明显的特征，并纳入了指南中。基于这些特征，为足部黑色素瘤起草了一个新的缩写词“CUBED”，并纳入了指南中。
结论
使用该指南可以帮助临床医生评估足部（包括甲单元）可疑病变。早期发现可疑的足部病变可能有助于更早地转介给专家进行评估和明确诊断。该指南目前正在临床医生中进行现场测试。
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