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基于边缘检测的GLP-1对糖尿病患者肾脏保护作用的临床分析

Clinical Analysis of the Renal Protective Effect of GLP-1 on Diabetic Patients Based on Edge Detection.

作者信息

Wang Jing, Wang Yang, Pang Ping, Jia Xiaomeng, Yan Xu, Lv Zhaohui

机构信息

Department of Clinical Nutrition, The 8th Medical Center of Chinese PLA General Hospital, Beijing 100091, China.

Department of Nephrology, The 8th Medical Center of Chinese PLA General Hospital, Beijing 100091, China.

出版信息

J Healthc Eng. 2022 Mar 22;2022:6504006. doi: 10.1155/2022/6504006. eCollection 2022.

Abstract

With the rapid development of IoT technology, it is a new trend to combine edge computing with smart medicine in order to better develop modern medicine, avoid the crisis of information "sibling," and meet the requirements of timeliness and computational performance of the massive data generated by edge devices. However, edge computing is somewhat open and prone to security risks, so the security and privacy protection of edge computing systems for smart healthcare is receiving increasing attention. The two groups were compared before and after treatment for blood glucose, blood lipids, blood pressure, renal function, serum advanced glycosylation end products (AGEs) and cyclic adenosine monophosphate (cAMP), serum oxidative stress indicators, and levels of cAMP/PKA signalling pathway-related proteins in peripheral blood mononuclear cells. The results of this study show that the reduction of AGEs, the improvement of oxidative stress, and the regulation of the cAMP/PKA signalling pathway may be associated with a protective effect against early DKD. By introducing the edge computing system and its architecture for smart healthcare, we describe the security risks encountered by smart healthcare in edge computing, introduce the solutions proposed by some scholars to address the security risks, and finally summarize the security protection framework and discuss the specific solutions for security and privacy protection under this framework, which will provide some help for the credible research of smart healthcare edge computing.

摘要

随着物联网技术的快速发展,将边缘计算与智能医疗相结合已成为一种新趋势,以便更好地发展现代医学,避免信息“孤岛”危机,并满足边缘设备产生的海量数据的及时性和计算性能要求。然而,边缘计算在一定程度上具有开放性,容易出现安全风险,因此智能医疗边缘计算系统的安全和隐私保护受到越来越多的关注。比较两组治疗前后的血糖、血脂、血压、肾功能、血清晚期糖基化终产物(AGEs)和环磷酸腺苷(cAMP)、血清氧化应激指标以及外周血单个核细胞中cAMP/PKA信号通路相关蛋白的水平。本研究结果表明,AGEs的降低、氧化应激的改善以及cAMP/PKA信号通路的调节可能与早期糖尿病肾病的保护作用有关。通过介绍智能医疗的边缘计算系统及其架构,我们描述了智能医疗在边缘计算中遇到的安全风险,介绍了一些学者提出的应对安全风险的解决方案,最后总结了安全保护框架并讨论了该框架下安全和隐私保护的具体解决方案,这将为智能医疗边缘计算的可信研究提供一些帮助。

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