撒丁岛人患1型糖尿病的方式。
The Sardinian way to type 1 diabetes.
作者信息
Songini Marco, Lombardo Cira
机构信息
Centre of Diabetes and Metabolic Disease, Department of Internal Medicine, San Michele Hospital, Cagliari, Sardinia, Italy.
出版信息
J Diabetes Sci Technol. 2010 Sep 1;4(5):1248-55. doi: 10.1177/193229681000400526.
Abstract
Sardinia and Finland are the "hottest" areas for type 1 diabetes mellitus (T1DM) worldwide. Its genetic and epidemiological background make Sardinia an ideal region for investigating environmental, immunological, and genetic factors related to the etiopathogenesis of T1DM. Consequently, in 1990, the Insulin-Dependent Diabetes Mellitus Sardinia Project was launched in order to map the geographical distribution of T1DM in the island and to investigate preclinical phases of T1DM in a large cohort of people genetically at risk. The final goal would be to design models of prediction and to formulate safe preventive measures, especially addressed to the general population living in areas at high risk.
摘要
撒丁岛和芬兰是全球1型糖尿病（T1DM）的“高发”地区。其遗传和流行病学背景使撒丁岛成为研究与T1DM病因发病机制相关的环境、免疫和遗传因素的理想区域。因此，1990年启动了撒丁岛胰岛素依赖型糖尿病项目，以绘制该岛T1DM的地理分布，并在一大群有遗传风险的人群中研究T1DM的临床前期阶段。最终目标是设计预测模型并制定安全的预防措施，特别是针对生活在高风险地区的普通人群。
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