Bottazzo G F, Loviselli A, Velluzzi F, Mariotti S, Cossu E, Cirillo R, Balestrieri A, Delitala G, Sepe V, Songini M
Department of Immunology, St Bartholomew's, London, United Kingdom.
Ann Ist Super Sanita. 1997;33(3):417-24.
Sardinia and Finland have the highest incidence of IDDM in the world. Thus, both regions represent ideal observatories for investigating the environmental, genetic and immunological factors, which have led to this dramatic increase. We have concentrated our efforts in Sardinia. Among several projects, there is the mapping of the Island for hot and cold spots for overt IDDM. In order to map the Island for pre-IDDM, we have collected and bled around 10,000 school children (age 6-14 years) and we are now in the process to enroll around 30,000 newborn. We report here our initial results, which show that progression to IDDM is accompanied in both cohorts by the presence of a combination of ICA with either GAD and IA-2 antibodies or both. This approach should lead to design reliable models of IDDM prediction in the general population, which will benefit an early insulin treatment and, hopefully, an effective prevention of the disease.
撒丁岛和芬兰是全球1型糖尿病发病率最高的地区。因此，这两个地区都是研究导致发病率急剧上升的环境、遗传和免疫因素的理想观察对象。我们把精力集中在了撒丁岛。在多个项目中，有一项是绘制该岛显性1型糖尿病的热点和冷点分布图。为了绘制该岛糖尿病前期的分布图，我们已采集了约10000名学童（6 - 14岁）的血液样本，目前正在招募约30000名新生儿。我们在此报告我们的初步结果，结果显示，在这两个队列中，1型糖尿病的进展都伴随着胰岛细胞抗体（ICA）与谷氨酸脱羧酶抗体（GAD）和胰岛抗原2抗体（IA - 2）其中之一或两者同时出现。这种方法应能促成在普通人群中设计出可靠的1型糖尿病预测模型，这将有助于早期胰岛素治疗，并有望有效预防该疾病。
