鉴定 GnRH 神经元电生理学：十年研究历程。
Identified GnRH neuron electrophysiology: a decade of study.
机构信息
Department of Molecular and Integrative Physiology, 7725 Med Sci II, 1301 E Catherine St., Ann Arbor, MI 48109-5622, USA.
出版信息
Brain Res. 2010 Dec 10;1364:10-24. doi: 10.1016/j.brainres.2010.09.066. Epub 2010 Nov 1.
Abstract
Over the past decade, the existence of transgenic mouse models in which reporter genes are expressed under the control of the gonadotropin-releasing hormone (GnRH) promoter has made possible the electrophysiological study of these cells. Here, we review the intrinsic and synaptic properties of these cells that have been revealed by these approaches, with a particular regard to burst generation. Advances in our understanding of neuromodulation of GnRH neurons and synchronization of this network are also discussed.
摘要
在过去的十年中，存在着一些转基因小鼠模型，其中报告基因在促性腺激素释放激素（GnRH）启动子的控制下表达，这使得对这些细胞进行电生理研究成为可能。在这里，我们回顾了这些方法所揭示的这些细胞的固有和突触特性，特别是关于爆发产生的内容。还讨论了我们对 GnRH 神经元的神经调节和这个网络的同步的理解的进展。
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