Institute of Toxicology of Kunming Medical University, Kunming, Yunnan, China.
Food Chem Toxicol. 2011 Jan;49(1):57-60. doi: 10.1016/j.fct.2010.09.031. Epub 2010 Oct 28.
Salaciachinensis is a traditional South and Southeast Asian herb medicine and has been reported to have an antidiabetic function via α-glucosidases inhibitory activity. In this study, the effects of S. chinensis extract (SCE) on reproductive functions of F0 males and females and the effects on survival and growth of F1 offspring were examined using Sprague-Dawley rats. SCE was administered at dose levels of 0, 500, 1000 and 2000 mg/kg/day orally to groups consisting of 25 males and 25 females. Males were dosed once a day in the morning from 8 weeks before mating, throughout the mating period and until the day before necropsy and females were dosed once a day in the morning for 2 weeks before mating and through the mating, gestation and lactation periods (until day 20 of lactation). In all SCE treatment groups, no toxic signs were noted on reproductive outcome such as estrous cycle of F0 females or any parameters for reproductive function or survival, growth, sensory reflex or function development of F1 pups. Therefore, we concluded that SCE has no effects on the reproductive outcome even at a remarkably high dosage level, 2000 mg/kg/day, in Sprague-Dawley rats.
盐肤木是一种传统的南亚和东南亚草药，据报道具有通过α-葡萄糖苷酶抑制活性的降血糖功能。在这项研究中，使用 Sprague-Dawley 大鼠检查了盐肤木提取物（SCE）对 F0 雌雄两性生殖功能的影响以及对 F1 后代存活和生长的影响。SCE 以 0、500、1000 和 2000mg/kg/天的剂量水平经口给予由 25 只雄性和 25 只雌性组成的各组。雄性每天早晨在交配前 8 周开始，整个交配期和解剖前一天每天给药一次，而雌性每天早晨在交配前 2 周和交配、妊娠和哺乳期（直至哺乳期第 20 天）给药一次。在所有 SCE 处理组中，未观察到 F0 雌性的动情周期或任何生殖功能或生存、生长、感觉反射或 F1 幼仔功能发育的参数等生殖结果出现毒性迹象。因此，我们得出结论，即使在 Sprague-Dawley 大鼠中以 2000mg/kg/天的显著高剂量水平，SCE 也不会对生殖结果产生影响。
