Koteshwar Pravina, Raveendra Kadur Ramamurthy, Allan Joseph Joshua, Goudar Krishnagouda Shankargouda, Venkateshwarlu Kudiganti, Agarwal Amit
Clinical Pharmacology, Institute of Clinical Research (India), Bangalore, India.
Pharmacogn Mag. 2013 Oct;9(36):344-9. doi: 10.4103/0973-1296.117831.
Salacia chinensis (S. chinensis) is widely distributed in India and Sri Lanka. Most of the species of genus Salacia are known to have effects on blood glucose levels; however, the effects of S. chinensis on glucose levels are seldom reported.
To evaluate the oral hypoglycemic activity of NR- Salacia (1000 mg extract of S. chinensis) in healthy adults.
Randomized, double-blind, placebo-controlled, cross-over study was conducted in healthy volunteers. Single dose of NR-Salacia (1000 mg extract of Salacia chinensis) and placebo were administered before carbohydrate-rich diet. A 6-point plasma glucose profile was performed at different time intervals up to 180 min.
NR-Salacia treatment significantly lowered plasma glucose level at 90 min, and the percentage reduction in glucose concentration was found to be 13.32 as compared to placebo group. A 33.85% decrease in the plasma glucose positive incremental area under curve (AUC) (0 to 180 min) was observed in comparison to placebo. No adverse events were recorded throughout the study period, except for some mild cases of abdominal discomforts like cramping and distention, vomiting, and headache in both placebo and NR-Salacia-treated groups.
The study findings revealed that NR-Salacia lowered the post-prandial plasma glucose levels after a carbohydrate-rich meal and can be used as an oral hypoglycemic agent.
中华五层龙（Salacia chinensis）广泛分布于印度和斯里兰卡。已知五层龙属的大多数物种对血糖水平有影响；然而，中华五层龙对血糖水平的影响鲜有报道。
评估NR-五层龙（中华五层龙1000毫克提取物）对健康成年人的口服降糖活性。
在健康志愿者中进行随机、双盲、安慰剂对照、交叉研究。在富含碳水化合物的饮食前给予单剂量的NR-五层龙（中华五层龙1000毫克提取物）和安慰剂。在长达180分钟的不同时间间隔进行六点血浆葡萄糖曲线测定。
NR-五层龙治疗在90分钟时显著降低了血浆葡萄糖水平，与安慰剂组相比，葡萄糖浓度降低百分比为13.32。与安慰剂相比，观察到血浆葡萄糖曲线下阳性增量面积（AUC）（0至180分钟）下降了33.85%。在整个研究期间，除了安慰剂组和NR-五层龙治疗组均出现一些轻度腹部不适，如绞痛、腹胀、呕吐和头痛外，未记录到不良事件。
研究结果表明，NR-五层龙降低了富含碳水化合物餐后的餐后血浆葡萄糖水平，可作为口服降糖药使用。
