血清尿酸水平可预测原发性高血压住院患者新发 2 型糖尿病：MAGIC 研究。
Serum uric acid levels predict new-onset type 2 diabetes in hospitalized patients with primary hypertension: the MAGIC study.
机构信息
Department of Cardionephrology, University of Genoa, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy.
出版信息
Diabetes Care. 2011 Jan;34(1):126-8. doi: 10.2337/dc10-0918. Epub 2010 Oct 4.
Abstract
OBJECTIVE
Recent studies suggest that uric acid may predict the development of diabetes in the general population. Whether this association holds true in primary hypertension and is independent of renal function and metabolic syndrome is not clear at present.
RESEARCH DESIGN AND METHODS
In a prospective, observational study, 758 untreated hypertensive patients were evaluated at baseline and followed-up for 11 years.
RESULTS
A total of 8,332 person-years of follow-up revealed that slightly elevated uric acid levels (i.e., ≥318 μmol/l for women and ≥420 μmol/l for men) at baseline were associated with a significantly higher risk of developing diabetes (hazard ratio 3.65 [95% CI 1.99-6.69], P < 0.0001), even after adjustment for several confounding factors such as metabolic syndrome (2.78 [1.35-5.70], P = 0.0054).
CONCLUSIONS
Uric acid is an independent predictor of diabetes in primary hypertension.
摘要
目的
最近的研究表明，尿酸可能预测普通人群中糖尿病的发生。目前尚不清楚这种关联在原发性高血压中是否存在，以及是否独立于肾功能和代谢综合征。
研究设计和方法
在一项前瞻性、观察性研究中，758 名未经治疗的高血压患者在基线时进行了评估，并随访了 11 年。
结果
总共 8332 人年的随访结果显示，基线时尿酸水平略有升高（即女性≥318 μmol/l，男性≥420 μmol/l）与发生糖尿病的风险显著增加相关（风险比 3.65[95%CI 1.99-6.69]，P<0.0001），即使在调整了代谢综合征等多种混杂因素后也是如此（2.78[1.35-5.70]，P=0.0054）。
结论
尿酸是原发性高血压中糖尿病的独立预测因子。
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