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前往睡眠医学中心就诊的慢性催眠药物使用者的持续性失眠:对137例连续患者的回顾性病历审查。

Persistent insomnia in chronic hypnotic users presenting to a sleep medical center: a retrospective chart review of 137 consecutive patients.

作者信息

Krakow Barry, Ulibarri Victor A, Romero Eddie

机构信息

Sleep and Human Health Institute, Albuquerque, NM 87109, USA.

出版信息

J Nerv Ment Dis. 2010 Oct;198(10):734-41. doi: 10.1097/NMD.0b013e3181f4aca1.

Abstract

Chronic insomnia patients may fail pharmacotherapy. We reviewed charts on 137 chronic insomnia patients new to our sleep medical center who reported persisting insomnia despite long-term usage of pharmacotherapy. We examined 4 areas: (1) patient views on encounters with prescribing physicians; (2) self-reported medication efficacy; (3) treatment-seeking goals; and (4) completion of a sleep medicine workup. Insomnia chronicity averaged 13 years; use of prescription medication for sleep averaged 3.81 years. Encounters with prescribing physicians yielded few options beyond drugs. Drug efficacy was not optimal for most of these patients. Sleeping better or drug-free were their chief goals. Subjective and objective sleep measures confirmed moderately severe residual insomnia as well as fair to poor waking impairment and quality of life. Sleep workup revealed high rates of maladaptive behavioral influences (96%), psychiatric complaints (89%), and obstructive sleep apnea (71%). In chronic insomnia patients who failed pharmacotherapy, comorbid mental and physical factors indicated a sleep disturbance complexity unlikely to respond fully to medication.

摘要

慢性失眠患者药物治疗可能无效。我们回顾了137名初诊于我们睡眠医学中心的慢性失眠患者的病历,这些患者报告称尽管长期使用药物治疗,但仍存在持续性失眠。我们检查了4个方面:(1)患者对与开处方医生接触的看法;(2)自我报告的药物疗效;(3)寻求治疗的目标;(4)完成睡眠医学检查。失眠的慢性病程平均为13年;使用处方睡眠药物的平均时长为3.81年。与开处方医生的接触除了药物之外几乎没有其他选择。对大多数这些患者来说,药物疗效并不理想。睡得更好或摆脱药物是他们的主要目标。主观和客观睡眠指标证实存在中度严重的残余失眠,以及轻度至中度的觉醒功能障碍和生活质量问题。睡眠检查显示适应不良行为影响的发生率很高(96%)、精神疾病主诉(89%)和阻塞性睡眠呼吸暂停(71%)。在药物治疗无效的慢性失眠患者中,合并的精神和身体因素表明睡眠障碍较为复杂,不太可能对药物治疗完全产生反应。

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