Lin Jingfeng, Wang Zhenyi, Tian Danfeng, Xi Run, Zhang Lina, Han Zhenyun
Department of Psychiatry, Afliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Beijing University of Chinese Medicine,Dongfang Hospital, Beijing, China.
Psychiatry Clin Psychopharmacol. 2025 Jul 28;35(3):295-303. doi: 10.5152/pcp.2025.24923.
Background: The prevalence of insomnia disorder is high among the general poulation and is a risk factor for many diseases. The rationality of drug use for insomnia in Chinese Medicine Hospital was uncertain. In order to evaluate the use of drugs in the Chinese Medicine Hospital of Longgang, Shenzhen, the authors conducted this cross-sectional research. Methods: A retrospective, cross-sectional study was conducted in Shenzhen Hospital of Beijing University of Chinese Medicine (Long Gang), Guangdong Province. Insomnia patients from January 1, 2016, to November 10, 2020, were included in the cross-sectional study. Patients corresponding to International Classification of Sleep Disorders (ISCD-3) Diagnostic Criteria for short-term and chronic insomnia were included. The authors excluded patients with severe mental disease or nervous system dysfunction or who could not correctly describe their symptoms. The characteristics of insomnia patients, survey results of drug use and symptoms of insomnia patients were collected. The authors analyzed the basic information, condition of drug use, and relationship between symptoms and drug use using R software (version 4.0.2) with the arulesViz package. Results: A total of 9439 patients were included in the study. The average age of these patients was 45.81 years (SD 13.97 years). Anxiety, dreaminess, dizziness, palpitation, headache, thirst, weakness, chest distress, annoyance, abdominal distension, bad moods, difficulty in falling asleep and bitter taste in the mouth were core symptoms of insomnia. The 10 most commonly used drugs ranged from more to less were estazolam (29.99%), Zaoren anshen capsule (15.50%), oryzanol (14.82%), diazepam (14.51%), flupentixol and melitracen (14.30%), alprazolam (8.12%), zolpidem tartrate (5.29%), vitamin B6 (4.76%), sertraline (4.03%), and clonazepam (2.97%). Conclusion: Drugs used for insomnia in the Chinese medicine hospital in Longgang, Shenzhen mainly included benzodiazepines, nonbenzodiazepines, Chinese patent medicines, anti-anxiety drugs, anti-depression drugs, oryzanol, and vitamin B6. The use of oryzanol and vitamin B6 was abused in Chinese medicine hospitals, and the use of Chinese medicine should be evaluated more rigorously. Nonbenzodiazepines should be promoted and more widely understood in the Chinese medicine hospital in Longgang, Shenzhen.
失眠障碍在普通人群中患病率较高，是多种疾病的危险因素。中医医院失眠用药的合理性尚不确定。为评估深圳市龙岗区中医医院的用药情况，作者开展了这项横断面研究。方法：在广东省深圳市北京中医药大学深圳医院（龙岗）进行回顾性横断面研究。纳入2016年1月1日至2020年11月10日的失眠患者进行横断面研究。纳入符合《国际睡眠障碍分类》（ISCD - 3）短期和慢性失眠诊断标准的患者。排除患有严重精神疾病或神经系统功能障碍或无法正确描述其症状的患者。收集失眠患者的特征、用药调查结果及失眠症状。作者使用R软件（版本4.0.2）及arulesViz包分析基本信息、用药情况以及症状与用药之间的关系。结果：共纳入9439例患者。这些患者的平均年龄为45.8（标准差13.97）岁。焦虑、多梦、头晕、心悸、头痛、口渴、乏力、胸闷、烦躁、腹胀、情绪不佳、入睡困难和口苦是失眠的核心症状。最常用的10种药物从多到少依次为艾司唑仑（29.99%）、枣仁安神胶囊（15.50%）、谷维素（14.82%）、地西泮（14.51%）、氟哌噻吨美利曲辛（14.30%）、阿普唑仑（8.12%）、酒石酸唑吡坦（5.29%）、维生素B6（4.76%）、舍曲林（4.03%）和氯硝西泮（2.97%）。结论：深圳市龙岗区中医医院失眠用药主要包括苯二氮䓬类、非苯二氮䓬类、中成药、抗焦虑药、抗抑郁药、谷维素和维生素B6。谷维素和维生素B6在中医医院存在滥用情况，中药的使用应更严格地评估。非苯二氮䓬类药物在深圳市龙岗区中医医院应得到推广并更广泛地认识。
