人类肿瘤抑制因子的功能机制。
Functional mechanisms for human tumor suppressors.
机构信息
Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan S7N 5C9, Canada.
出版信息
J Cancer. 2010 Sep 15;1:136-40. doi: 10.7150/jca.1.136.
Abstract
Tumor suppressors refer to a large group of molecules that are capable of controlling cell division, promoting apoptosis, and suppressing metastasis. The loss of function for a tumor suppressor may lead to cancer due to uncontrolled cell division. Because of their importance, extensive studies have been undertaken to understand the different functional mechanisms of tumor suppressors. Here, we briefly review the four major mechanisms, inhibition of cell division, induction of apoptosis, DNA damage repair, and inhibition of metastasis. It is noteworthy that some tumor suppressors, such as p53, may adopt more than one mechanism for their functions.
摘要
肿瘤抑制因子是指一大类能够控制细胞分裂、促进细胞凋亡和抑制转移的分子。肿瘤抑制因子功能丧失可能导致细胞不受控制地分裂，从而引发癌症。由于其重要性，人们已经进行了广泛的研究来了解肿瘤抑制因子的不同功能机制。在这里，我们简要回顾了四种主要机制，即抑制细胞分裂、诱导细胞凋亡、DNA 损伤修复和抑制转移。值得注意的是，一些肿瘤抑制因子，如 p53，可能采用多种机制来发挥其功能。
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