利用癌症基因组学改变诊断和治疗方法。

Transforming Diagnosis and Therapeutics Using Cancer Genomics.

机构信息

Department of Biological Sciences, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan.

Department of Bioinformatics and Biosciences, Faculty of Health and Life Sciences, Capital University of Science and Technology (CUST) Islamabad, Islamabad, Pakistan.

出版信息

Cancer Treat Res. 2023;185:15-47. doi: 10.1007/978-3-031-27156-4_2.

DOI:10.1007/978-3-031-27156-4_2

PMID:37306902

Abstract

In past quarter of the century, much has been understood about the genetic variation and abnormal genes that activate cancer in humans. All the cancers somehow possess alterations in the DNA sequence of cancer cell's genome. In present, we are heading toward the era where it is possible to obtain complete genome of the cancer cells for their better diagnosis, categorization and to explore treatment options.

摘要

在过去的四分之一个世纪中，人们对导致人类癌症的遗传变异和异常基因有了更多的了解。所有的癌症在某种程度上都存在癌细胞基因组中 DNA 序列的改变。现在，我们正朝着这样一个时代迈进，即有可能获得癌细胞的完整基因组，以便更好地进行诊断、分类，并探索治疗方案。