Department of Cytopathology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Gynecol Oncol. 2010 Sep;21(3):199-202. doi: 10.3802/jgo.2010.21.3.199. Epub 2010 Sep 28.
Primary malignant melanoma of the uterine cervix is a rare neoplasm with poor prognosis. It may be misdiagnosed especially when amelanotic, in which case immunohistochemistry is useful in reaching the diagnosis. We present one such case of a 65-year-old postmenopausal female patient presenting with bleeding per vaginum. Speculum examination revealed an ulcero-proliferative growth involving the cervix. On histopathological examination it was originally suspected to be a poorly differentiated carcinoma or a non-epithelial malignant tumor, but was subsequently correctly diagnosed by immunohistochemical staining with the HMB-45 antibody and S-100 protein.
宫颈原发性恶性黑色素瘤是一种罕见的肿瘤，预后不良。特别是当肿瘤无色素沉着时，可能会被误诊，此时免疫组织化学检查有助于明确诊断。我们报告了这样一个病例：一名 65 岁绝经后女性患者因阴道出血就诊。阴道镜检查显示宫颈有溃疡增殖性生长。组织病理学检查最初怀疑为低分化癌或非上皮性恶性肿瘤，但随后通过 HMB-45 抗体和 S-100 蛋白的免疫组织化学染色正确诊断。
