Pang Yingxin, Yuan Hang, Ren Anji, Zhang Shiqian, Liu Peishu
Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan.
Department of Urology, Weifang Traditional Chinese Hospital, Weifang, Shandong, China.
Medicine (Baltimore). 2019 Jul;98(30):e16366. doi: 10.1097/MD.0000000000016366.
Primary melanomas of the female genital tract are rare and usually occur in the vulva and vagina. Involvement of the cervix, uterus, and ovary are extremely rare. Surgery and adjuvant therapy remain the mainstay of treatment. The majority of patients experience poor long-term survival. This report aimed at highlighting an extremely rare case of primary melanoma of the female genitalia, synchronously involving the vulva and uterine cervix.
A 58-year-old multiparous female presented with postmenopausal bleeding for 10 days.
Speculum examination and histologic analysis of the surgical specimens revealed synchronous involvement of the vulva and uterine cervix by malignant melanoma. According to the American Joint Committee on Cancer stage grouping for melanoma, this tumor was at stage V.
The patient subsequently underwent radical surgery and postoperative chemotherapy.
She has been on regular follow-up, and is now free of disease for 50 months after the operation.
Primary melanomas of the female genital tract have biologically aggressive characteristics. Optimal management consists of individualized surgery and adjuvant therapy. However, early recognition and prompt intervention offer maximal benefit from treatment.
女性生殖道原发性黑色素瘤较为罕见，通常发生在外阴和阴道。宫颈、子宫和卵巢受累极为罕见。手术及辅助治疗仍是主要的治疗手段。大多数患者长期生存率较低。本报告旨在强调一例极为罕见的女性生殖器原发性黑色素瘤病例，该病例同时累及外阴和子宫颈。
一名58岁经产妇，绝经后阴道出血10天。
窥器检查及手术标本的组织学分析显示，恶性黑色素瘤同时累及外阴和子宫颈。根据美国癌症联合委员会黑色素瘤分期分组，该肿瘤处于V期。
患者随后接受了根治性手术及术后化疗。
她一直在定期随访，术后50个月目前无疾病复发。
女性生殖道原发性黑色素瘤具有生物学侵袭性特征。最佳治疗方案包括个体化手术及辅助治疗。然而，早期识别和及时干预能使治疗获益最大化。
