Lung Immunobiology Group, Institute of Cellular Medicine, 4th Floor, William Leech Building, Medical School, Framlington Place, Newcastle University, NE2 4HH, UK.
Expert Rev Respir Med. 2010 Oct;4(5):647-60. doi: 10.1586/ers.10.62.
Physiological lung epithelial wound repair is a complex, highly orchestrated process presenting numerous points where dysregulation may occur, leading to the development of several pulmonary disorders. Current studies are limited by a lack of relevant lung injury models, with much work relying on other organ models such as the skin or in vitro cultures. However, much promising investigative work is being undertaken, some of which is described in this article. This article attempts to describe the processes required to heal a severe wound to the airway epithelium, characteristic of several chronic pulmonary disorders, highlighting areas where dysregulation may occur, which in turn leads to the development or continuation of a disease state.
生理肺上皮伤口修复是一个复杂的、高度协调的过程，存在许多可能失调的点，从而导致多种肺部疾病的发生。目前的研究受到缺乏相关肺损伤模型的限制，许多工作依赖于其他器官模型，如皮肤或体外培养。然而，正在进行大量有前景的研究工作，本文介绍了其中的一部分。本文试图描述修复气道上皮严重创伤所需的过程，这些创伤是几种慢性肺部疾病的特征，强调可能失调的区域，这反过来又导致疾病状态的发展或持续。
