Yu Yao, Liu Yuxi, Lu Fei, Fang Luping, Ning Gangmin, Pan Qing
College of Information Engineering, Zhejiang University of Technology, 288 Liuhe Road, Hangzhou 310023, China.
Moganshan Institute, Zhejiang University of Technology, 926 Changhong East Road, Deqing 313200, China.
Life (Basel). 2025 May 22;15(6):835. doi: 10.3390/life15060835.
Mechanical ventilation, a lifesaving intervention for critically ill patients, can also cause ventilator-induced lung injury (VILI), which is related to its interplay with immune system. To explore this relationship, we established a model consisting of two subsystems: a lung immune response system (LIRS), elucidating the interactions between immune cells and epithelial cells within the pulmonary environment, and a tidal volume damage system (TVDS), quantifying alveolar epithelial damage by simulating the detrimental effects of mechanical ventilation across varying tidal volumes. The integrated framework presents a novel lens for examining the interplay between heterogeneous immunological capabilities and tidal volume. The model reveals distinct responses among the individuals with varying immune capacities when subjected to identical tidal volumes, manifesting in diverse outcomes for healthy epithelial cells (). Analysis of simulation results shows a weak correlation between initial immune cell variables and , and a stronger correlation between and baseline repair capacity. Furthermore, while the initial immune state of lung tissue moderately influences epithelial health, the heterogeneous and inherent immunological competence of the tissue plays a pivotal role in shaping the diverse patterns observed in the development and severity of VILI. This insight highlights the importance of tailoring therapeutic strategies to individual immunological profiles, thereby optimizing patient outcomes.
机械通气作为一种用于重症患者的挽救生命的干预措施，也可能导致呼吸机诱导的肺损伤（VILI），这与其与免疫系统的相互作用有关。为了探究这种关系，我们建立了一个由两个子系统组成的模型：一个肺免疫反应系统（LIRS），用于阐明肺环境中免疫细胞与上皮细胞之间的相互作用；一个潮气量损伤系统（TVDS），通过模拟不同潮气量下机械通气的有害影响来量化肺泡上皮损伤。这个综合框架为研究异质性免疫能力与潮气量之间的相互作用提供了一个全新的视角。该模型揭示了在相同潮气量下，具有不同免疫能力的个体之间存在不同的反应，表现为健康上皮细胞的不同结果。模拟结果分析表明，初始免疫细胞变量与[此处原文缺失相关内容]之间的相关性较弱，而[此处原文缺失相关内容]与基线修复能力之间的相关性较强。此外，虽然肺组织的初始免疫状态对上皮健康有一定程度的影响，但组织的异质性和固有免疫能力在塑造VILI发展和严重程度中观察到的不同模式方面起着关键作用。这一见解凸显了根据个体免疫特征制定治疗策略的重要性，从而优化患者预后。
