LYYN 使人类组胺风团的颜色变化可见：一种增强颜色差异的技术。

Colour change in the human histamine wheal made visible by LYYN: a technique to enhance colour differences.

机构信息

Department of Electrical Measurements, Lund University, Lund, Sweden.

出版信息

Skin Res Technol. 2010 Nov;16(4):385-9. doi: 10.1111/j.1600-0846.2010.00457.x.

DOI:10.1111/j.1600-0846.2010.00457.x

PMID:20923457

Abstract

BACKGROUND

Colour differences in photographs can be enhanced using a digital image-processing technique called LYYN.

OBJECTIVE

To investigate colour changes in the histamine wheal after skin prick tests (SPTs).

METHODS

Histamine SPTs were performed on the forearm of six medical students, and the reactions of the skin were photographed every 2min for 30min. Colour differences in the photographs were then enhanced using the LYYN technique. These images were processed using ImageJ to yield numerical values.

RESULTS

In the LYYN-processed images, there was a rapid colour change in the histamine wheals between the 18th and the 20th minute (P<0.01). Histamine perfusion in isolated rabbit ears indicated vasodilatation in post-capillary vessels and desensitized histamine 1 (H1) receptors after a mean of 17min. It is possible that a similar desensitization takes place in the human histamine wheal, and a study of two histamine SPTs 90 min apart at the same site supports this hypothesis.

CONCLUSION

The LYYN technique was sensitive enough to discover a rapid colour change in the histamine wheal, a change that has not been described before.

摘要

背景

一种名为 LYYN 的数字图像处理技术可以增强照片中的色彩差异。

目的

研究皮肤点刺试验（SPT）后组织胺风团的颜色变化。

方法

在六名医学生的前臂上进行组织胺 SPT，并在 30 分钟内每 2 分钟拍摄一次皮肤反应的照片。然后使用 LYYN 技术增强照片中的色彩差异。使用 ImageJ 对这些图像进行处理以获得数值。

结果

在 LYYN 处理的图像中，组织胺风团在第 18 分钟至第 20 分钟之间迅速变色（P<0.01）。平均 17 分钟后，在孤立的兔耳中观察到组织胺灌注，表明毛细血管后血管扩张和 H1 受体脱敏。在人类组织胺风团中可能发生类似的脱敏，一项在同一部位相隔 90 分钟进行的两项组织胺 SPT 研究支持这一假说。