Department of Electrical Engineering, National Dong Hwa University, Hualien 97401, Taiwan.
IEEE Trans Biomed Eng. 2011 Feb;58(2):243-52. doi: 10.1109/TBME.2010.2084087. Epub 2010 Oct 4.
Although current technique of photoplethysmography (PPG) is a popular noninvasive method of waveform contour analysis in assessing arterial stiffness, data obtained are frequently affected by various environmental and physiological factors. We proposed an easily operable air pressure sensing system (APSS) for radial arterial signal capturing. Totally, 108 subjects (young, the aged with or without diabetes) were recruited from July 2009 to May 2010. Arterial waveform signals from the wrist were obtained and analyzed using Hilbert-Huang transformation (HHT). Through ensemble empirical mode decomposition (EEMD), the signals were decomposed into eight intrinsic mode functions (IMF1-8) of which IMF5 was found to be the desired signal with a discernible diastolic peak. The results showed significant differences in reflection index (RI) and stiffness index (SI) from the young subjects and those from the aged participants with or without diabetes. Significant differences in RI and SI were also noted between subjects with well-controlled diabetes and those without. Good reproducibility and correlation were demonstrated. In conclusion, the present study proposed the application of radial arterial signal capturing subsystem and HHT in acquiring more reliable data on RI and SI compared with the conventional PPG method.
尽管目前的光体积描记法（PPG）技术是一种用于评估动脉僵硬度的流行的无创波形轮廓分析方法，但所获得的数据经常受到各种环境和生理因素的影响。我们提出了一种易于操作的气压感应系统（APSS），用于采集桡动脉信号。总共从 2009 年 7 月至 2010 年 5 月招募了 108 名受试者（年轻人、有或没有糖尿病的老年人）。使用希尔伯特-黄变换（HHT）从手腕获取动脉波形信号并进行分析。通过集合经验模态分解（EEMD），将信号分解为八个固有模态函数（IMF1-8），其中 IMF5 是具有明显舒张峰值的所需信号。结果表明，年轻人与老年人（无论是否患有糖尿病）的反射指数（RI）和僵硬度指数（SI）存在显著差异。在糖尿病控制良好的患者和无糖尿病的患者之间，RI 和 SI 也存在显著差异。显示出良好的可重复性和相关性。总之，本研究提出了应用桡动脉信号采集子系统和 HHT 来获取比传统 PPG 方法更可靠的 RI 和 SI 数据。
