Gallagher David, Adji Audrey, O'Rourke Michael F
St. Vincent's Hospital, University of New South Wales, Sydney, Australia.
Am J Hypertens. 2004 Nov;17(11 Pt 1):1059-67. doi: 10.1016/j.amjhyper.2004.05.027.
Central aortic pressure waveforms can be calculated from the radial artery pressure waveform using a generalized transfer function to correct for pressure wave distortion in the upper limb. Although validated to standards conventionally applied, reservations are still expressed on use of this process, because of the relatively small number of patients from whom appropriate invasive data were obtained. The study described here supplemented such data with noninvasive data obtained from carotid and radial artery tonometry in 439 patients and normal subjects. The carotid-radial artery transfer function was similar to the aortic-radial when allowance was made for wave travel from aorta to carotid artery. The carotid-radial transfer function was identical in male and female individuals, was similar at different arterial pressures and in mature adults. Differences are relatively small, are seen at frequencies where central pressure wave components are small and are similar to those seen with vasodilator agents in invasive studies. Findings provide further support for use of a generalized transfer function to calculate aortic from upper limb pressure and conform with previously established views on vascular impedance.
可使用广义传递函数根据桡动脉压力波形计算中心主动脉压力波形，以校正上肢压力波失真。尽管该方法已按照传统应用标准进行了验证，但由于获取适当有创数据的患者数量相对较少，人们对使用该方法仍有所保留。本研究通过对439例患者和正常受试者进行颈动脉和桡动脉张力测量获得的无创数据补充了此类数据。当考虑到压力波从主动脉传播到颈动脉时，颈动脉-桡动脉传递函数与主动脉-桡动脉传递函数相似。颈动脉-桡动脉传递函数在男性和女性个体中相同，在不同动脉压力下以及在成年人中相似。差异相对较小，出现在中心压力波分量较小的频率处，并且与有创研究中使用血管扩张剂时观察到的差异相似。研究结果为使用广义传递函数从上肢压力计算主动脉压力提供了进一步支持，并与先前关于血管阻抗的既定观点一致。
