Hospital for Special Surgery, 535 E. 70th Street, New York, NY 10021, USA.
J Dent Res. 2010 Dec;89(12):1333-48. doi: 10.1177/0022034510377791. Epub 2010 Oct 5.
Bones provide mechanical and protective function, while also serving as housing for marrow and a site for regulation of calcium ion homeostasis. The properties of bones do not remain constant with age; rather, they change throughout life, in some cases improving in function, but in others, function deteriorates. Here we review the modifications in the mechanical function and shape of bones, the bone cells, the matrix they produce, and the mineral that is deposited on this matrix, while presenting recent theories about the factors leading to these changes.
骨骼具有机械和保护功能,同时也是骨髓的住所,也是调节钙离子平衡的场所。骨骼的特性并非一成不变,而是随着年龄的增长而发生变化,在某些情况下,功能会得到改善,但在其他情况下,功能会恶化。在这里,我们回顾了骨骼的机械功能和形状、骨细胞、它们产生的基质以及沉积在该基质上的矿物质的变化,并介绍了导致这些变化的因素的最新理论。