衰老对细胞机械转导的影响。
Effect of aging on cellular mechanotransduction.
机构信息
Cell Differentiation and Development Center, Marshall University, Huntington, WV, United States.
出版信息
Ageing Res Rev. 2011 Jan;10(1):1-15. doi: 10.1016/j.arr.2009.11.002. Epub 2009 Nov 20.
Abstract
Aging is becoming a critical heath care issue and a burgeoning economic burden on society. Mechanotransduction is the ability of the cell to sense, process, and respond to mechanical stimuli and is an important regulator of physiologic function that has been found to play a role in regulating gene expression, protein synthesis, cell differentiation, tissue growth, and most recently, the pathophysiology of disease. Here we will review some of the recent findings of this field and attempt, where possible, to present changes in mechanotransduction that are associated with the aging process in several selected physiological systems, including musculoskeletal, cardiovascular, neuronal, respiratory systems and skin.
摘要
衰老是一个严重的健康问题，也是社会日益沉重的经济负担。机械转导是细胞感知、处理和响应机械刺激的能力，是调节生理功能的重要调节因子，已发现其在调节基因表达、蛋白质合成、细胞分化、组织生长以及最近的疾病病理生理学中发挥作用。在这里，我们将回顾该领域的一些最新发现，并尝试在可能的情况下，介绍与几个选定的生理系统（包括肌肉骨骼、心血管、神经和呼吸系统以及皮肤）的衰老过程相关的机械转导变化。
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