Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Nat Struct Mol Biol. 2010 Oct;17(10):1164-5. doi: 10.1038/nsmb1010-1164.
The N-end rule pathway is a proteolytic system in which recognition components (N-recognins) recognize a set of N-terminal residues as part of degradation signals (N-degrons). Two studies in this issue report the structures of Ubr boxes, a substrate recognition domain of eukaryotic N-recognins. We discuss how eukaryotic and prokaryotic N-recognins use a similar molecular principle to recognize a different set of N-degrons.
N-端规则途径是一种蛋白水解系统，其中识别成分（N-识别蛋白）识别一组 N-末端残基作为降解信号（N-降解基）的一部分。本期的两项研究报告了真核 N-识别蛋白的底物识别结构域 Ubr 盒的结构。我们讨论了真核和原核 N-识别蛋白如何使用相似的分子原理来识别不同的 N-降解基。
