Nutritional Physiology, Institute of Nutrition and Food Science, University of Bonn, 53115, Bonn, Germany.
Eur J Appl Physiol. 2011 May;111(5):869-73. doi: 10.1007/s00421-010-1674-5. Epub 2010 Oct 6.
Our objective was to investigate the effect of quercetin supplementation on fasting resting energy expenditure (REE) and respiratory quotient (RQ) in humans. Six healthy, normal-weight women (mean age 25.5 ± 1.6 years, body mass index 21.4 ± 1.5 kg/m(2)) participated in a randomized, placebo-controlled, double-blinded crossover study. Treatments were administered as capsules of 150 mg quercetin (aglycone) or placebo. The acute response was measured by indirect calorimetry for 3 h following ingestion. Blood pressure and pulse rate were assessed in 30-min intervals. On the following day, 24 h after capsule intake, a follow-up measurement was performed. Baseline (t (0)) REE adjusted for fat-free mass was 4.7 ± 0.26 kJ/min (quercetin) and 4.8 ± 0.35 kJ/min (placebo) and did not significantly change between baseline and end (t (180)) in either group (P = 0.992 for time effect in repeated measures analysis of variance; P = 0.581 for time × treatment interaction). Mean RQ was 0.78 ± 0.04 (quercetin) and 0.77 ± 0.04 (placebo). RQ values decreased slowly and to a similar extent during both treatments (P < 0.001 for time; quercetin, -0.09 ± 0.05; placebo, -0.08 ± 0.03; P = 0.877 for time × treatment interaction). Resting systolic and diastolic blood pressure, pulse pressure as well as resting pulse rate did not significantly change between baseline and end in either treatment group. No significant differences were found between the results of the baseline measurement and 24 h after treatment. In conclusion, the present pilot study provides no evidence for a thermic effect of quercetin in humans.
我们的目的是研究槲皮素补充对人体空腹静息能量消耗（REE）和呼吸商（RQ）的影响。六名健康、体重正常的女性（平均年龄 25.5±1.6 岁，体重指数 21.4±1.5kg/m2）参与了一项随机、安慰剂对照、双盲交叉研究。治疗方法为口服 150mg 槲皮素（苷元）或安慰剂胶囊。在摄入后 3 小时内通过间接测热法测量急性反应。每 30 分钟评估一次血压和脉搏率。次日，在胶囊摄入后 24 小时进行后续测量。调整无脂肪质量的基础（t(0)）REE 为 4.7±0.26kJ/min（槲皮素）和 4.8±0.35kJ/min（安慰剂），两组在基线和终点（t(180)）之间均无显著变化（重复测量方差分析的时间效应 P=0.992；时间×处理相互作用 P=0.581）。平均 RQ 为 0.78±0.04（槲皮素）和 0.77±0.04（安慰剂）。在两种治疗中，RQ 值均缓慢且以相似的程度下降（P<0.001，时间；槲皮素，-0.09±0.05；安慰剂，-0.08±0.03；时间×处理相互作用 P=0.877）。在两种治疗组中，基线和终点之间静息收缩压、舒张压、脉压和静息脉搏率均无显著变化。在治疗后 24 小时和基线测量结果之间未发现显著差异。总之，本初步研究未提供槲皮素对人体有热效应的证据。
