University of Connecticut School of Pharmacy, Storrs, CT, USA.
Am J Clin Nutr. 2010 Jan;91(1):73-81. doi: 10.3945/ajcn.2009.28157. Epub 2009 Nov 11.
Green tea catechins (GTCs) with or without caffeine have been studied in randomized controlled trials (RCTs) for their effect on anthropometric measures and have yielded conflicting results.
The objective was to perform a systematic review and meta-analysis of RCTs of GTCs on anthropometric variables, including body mass index (BMI), body weight, waist circumference (WC), and waist-to-hip ratio (WHR).
A systematic literature search of MEDLINE, EMBASE, CENTRAL, and the Natural Medicines Comprehensive Database was conducted through April 2009. RCTs that evaluated GTCs with or without caffeine and that reported BMI, body weight, WC, or WHR were included. The weighted mean difference of change from baseline (with 95% CIs) was calculated by using a random-effects model.
Fifteen studies (n = 1243 patients) met the inclusion criteria. On meta-analysis, GTCs with caffeine decreased BMI (-0.55; 95% CI: -0.65, -0.40), body weight (-1.38 kg; 95% CI: -1.70, -1.06), and WC (-1.93 cm; 95% CI: -2.82, -1.04) but not WHR compared with caffeine alone. GTC ingestion with caffeine also significantly decreased body weight (-0.44 kg; 95% CI: -0.72, -0.15) when compared with a caffeine-free control. Studies that evaluated GTCs without concomitant caffeine administration did not show benefits on any of the assessed anthropometric endpoints.
The administration of GTCs with caffeine is associated with statistically significant reductions in BMI, body weight, and WC; however, the clinical significance of these reductions is modest at best. Current data do not suggest that GTCs alone positively alter anthropometric measurements.
已有的随机对照试验（RCT）研究了绿茶儿茶素（GTCs）联合或不联合咖啡因对人体测量学指标的影响，但结果相互矛盾。
对 GTCs 干预人体测量学变量（包括体重指数[BMI]、体重、腰围[WC]和腰臀比[WHR]）的 RCT 进行系统评价和荟萃分析。
系统检索了 MEDLINE、EMBASE、CENTRAL 和天然药物综合数据库，检索时间截至 2009 年 4 月。纳入了评估 GTCs 联合或不联合咖啡因且报告 BMI、体重、WC 或 WHR 的 RCT。采用随机效应模型计算从基线变化的加权均数差（95%CI）。
15 项研究（n = 1243 例患者）符合纳入标准。荟萃分析结果显示，与单独使用咖啡因相比，GTCs 联合咖啡因可降低 BMI（-0.55；95%CI：-0.65，-0.40）、体重（-1.38kg；95%CI：-1.70，-1.06）和 WC（-1.93cm；95%CI：-2.82，-1.04），但对 WHR 无影响。与不含咖啡因的对照组相比，GTCs 联合咖啡因还可显著降低体重（-0.44kg；95%CI：-0.72，-0.15）。单独给予 GTCs 而不联合使用咖啡因则对所有评估的人体测量学终点均无获益。
GTCs 联合咖啡因可使 BMI、体重和 WC 显著降低，但降低幅度的临床意义不大。目前的数据并不提示 GTCs 可单独对人体测量学指标产生积极影响。
