Bosy-Westphal Anja, Danielzik Sandra, Becker Christine, Geisler Corinna, Onur Simone, Korth Oliver, Bührens Frederike, Müller Manfred J
Institut für Humanernährung und Lebensmittelkunde der Christian-Albrechts University Kiel, Germany.
J Nutr. 2005 Sep;135(9):2257-62. doi: 10.1093/jn/135.9.2257.
Air-displacement plethysmography (ADP) is now widely used for body composition measurement in pediatric populations. However, the manufacturer's software developed for adults leaves a potential bias for application in children and adolescents, and recent publications do not consistently use child-specific corrections. Therefore we analyzed child-specific ADP corrections with respect to quantity and etiology of bias compared with adult formulas. An optimal correction protocol is provided giving step-by-step instructions for calculations. In this study, 258 children and adolescents (143 girls and 115 boys ranging from 5 to 18 y) with a high prevalence of overweight or obesity (28.0% in girls and 22.6% in boys) were examined by ADP applying the manufacturer's software as well as published equations for child-specific corrections for surface area artifact (SAA), thoracic gas volume (TGV), and density of fat-free mass (FFM). Compared with child-specific equations for SAA, TGV, and density of FFM, the mean overestimation of the percentage of fat mass using the manufacturer's software was 10% in children and adolescents. Half of the bias derived from the use of Siri's equation not corrected for age-dependent differences in FFM density. An additional 3 and 2% of bias resulted from the application of adult equations for prediction of SAA and TGV, respectively. Different child-specific equations used to predict TGV did not differ in the percentage of fat mass. We conclude that there is a need for child-specific equations in ADP raw data analysis considering SAA, TGV, and density of FFM.
空气置换体积描记法（ADP）目前广泛用于儿科人群的身体成分测量。然而，制造商为成年人开发的软件在应用于儿童和青少年时存在潜在偏差，并且最近的出版物并未始终如一地使用针对儿童的校正方法。因此，我们分析了与成人公式相比，针对儿童的ADP校正方法在偏差数量和病因方面的情况。提供了一种最佳校正方案，给出了计算的分步说明。在本研究中，对258名超重或肥胖患病率较高（女孩为28.0%，男孩为22.6%）的儿童和青少年（143名女孩和115名男孩，年龄在5至18岁之间）进行了ADP检查，使用了制造商的软件以及已发表的针对表面积伪影（SAA）、胸腔气体体积（TGV）和去脂体重（FFM）密度的儿童专用校正公式。与针对SAA、TGV和FFM密度的儿童专用公式相比，使用制造商的软件时，儿童和青少年脂肪量百分比的平均高估为10%。一半的偏差源于使用未针对FFM密度的年龄依赖性差异进行校正的西里方程。另外分别有3%和2%的偏差是由于应用成人公式预测SAA和TGV导致的。用于预测TGV的不同儿童专用公式在脂肪量百分比方面没有差异。我们得出结论，在考虑SAA、TGV和FFM密度的ADP原始数据分析中，需要针对儿童的公式。
