Savas Erdeve S, Simsek E, Dallar Yildiz, Biyikli Zeynep
Department of Pediatrics, Division of Pediatric Endocrinology, Ankara University School of Medicine, Ulusoy 312 City No: 16 B46, Cayyolu, 06830, Ankara, Turkey.
Indian J Pediatr. 2010 Nov;77(11):1261-5. doi: 10.1007/s12098-010-0217-8. Epub 2010 Oct 6.
To assess whether apoB/apoA1 ratio is associated or not with metabolic syndrome in obese children.
A 198 obese children and 41 healthy control subjects were enrolled in a cross-sectional study. The apoB/apoA1 ratio and other metabolic syndrome components in obese children with/without metabolic syndrome were compared to healthy controls.
The apoA1 level did not show significant difference (p = 0.664) but apoB level (p = 0.000) and apoB/apoA1 ratio (p = 0.001) were significantly higher in obese group than in control group. Also, the apoB/apoA1 ratio was significantly higher in obese children with metabolic syndrome when compared to obese children without metabolic syndrome (p = 0.007) and showed positive correlation with triglyceride (r = 0.404, p = 0.000) and negative correlation with high-density lipoprotein cholesterol (r = -0.593, p = 0.000).
The apoB/apoA1 ratio is associated with metabolic syndrome in obese children. An elevated apoB/apoA1 ratio may constitute an important feature of the metabolic syndrome. There is a need for long term follow-up studies concerning cardiovascular risk in obese children with metabolic syndrome and high apoB/apoA1 ratio.
评估载脂蛋白B/载脂蛋白A1比值是否与肥胖儿童的代谢综合征相关。
一项横断面研究纳入了198名肥胖儿童和41名健康对照者。将患有/未患有代谢综合征的肥胖儿童的载脂蛋白B/载脂蛋白A1比值及其他代谢综合征组分与健康对照者进行比较。
肥胖组的载脂蛋白A1水平无显著差异（p = 0.664），但载脂蛋白B水平（p = 0.000）和载脂蛋白B/载脂蛋白A1比值（p = 0.001）显著高于对照组。此外，患有代谢综合征的肥胖儿童的载脂蛋白B/载脂蛋白A1比值显著高于未患有代谢综合征的肥胖儿童（p = 0.007），且与甘油三酯呈正相关（r = 0.404，p = 0.000），与高密度脂蛋白胆固醇呈负相关（r = -0.593，p = 0.000）。
载脂蛋白B/载脂蛋白A1比值与肥胖儿童的代谢综合征相关。升高的载脂蛋白B/载脂蛋白A1比值可能构成代谢综合征的一个重要特征。有必要对患有代谢综合征且载脂蛋白B/载脂蛋白A1比值高的肥胖儿童的心血管风险进行长期随访研究。
