Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Nutr Cancer. 2010;62(7):871-7. doi: 10.1080/01635581.2010.509534.
We considered flavonoids and proanthocyanidins in a network of multicentric Italian case-control studies including about 10,000 incident, histologically confirmed cases of selected cancers and over 16,000 controls. Odds ratios (ORs) for the highest vs. the lowest quintile of 6 classes of flavonoids and proanthocyanidins were estimated by multiple logistic regression models. Total flavonoids, flavanones, and flavonols were inversely related to oral and laryngeal cancers (ORs, respectively 0.56 and 0.60 for total flavonoids; 0.51 and 0.60 for flavanones; and 0.62 and 0.32 for flavonols). Flavanols were also inversely related to laryngeal cancer (OR = 0.64), whereas flavanones were inversely related to esophageal cancer (OR = 0.38). A reduced risk of colorectal cancer was found for high intake of anthocyanidins (OR = 0.67), flavonols (OR = 0.64), flavones (OR = 0.78), and isoflavones (OR = 0.76). Inverse relations with breast cancer were found for flavones (OR = 0.81) and flavonols (OR = 0.80). Flavonols (OR = 0.63) and isoflavones (OR = 0.51) were inversely associated to ovarian cancer, whereas flavonols (OR = 0.69) and flavones (OR = 0.68) were inversely associated to renal cancer. No association between flavonoids and prostate cancer emerged. We found inverse associations between proanthocyanidins and colorectal cancer. These associations appeared stronger for proanthocyanidins with a higher degree of polymerization (OR = 0.69 for ≥ 10 mers).
我们在一项包含约 10000 例选定癌症的病例对照研究网络中考虑了类黄酮和原花青素，这些研究是在意大利多个中心进行的，并且包含超过 16000 例对照。使用多因素逻辑回归模型估计了 6 类类黄酮和原花青素的最高五分位数与最低五分位数的比值比（OR）。总类黄酮、黄烷酮和黄酮醇与口腔癌和喉癌呈负相关（总类黄酮的比值比分别为 0.56 和 0.60；黄烷酮为 0.51 和 0.60；黄酮醇为 0.62 和 0.32）。黄烷醇也与喉癌呈负相关（OR = 0.64），而黄烷酮与食管癌呈负相关（OR = 0.38）。花青素（OR = 0.67）、黄酮醇（OR = 0.64）、黄酮（OR = 0.78）和异黄酮（OR = 0.76）的高摄入量与结直肠癌风险降低有关。类黄酮（OR = 0.81）和黄酮醇（OR = 0.80）与乳腺癌呈负相关。黄酮醇（OR = 0.63）和异黄酮（OR = 0.51）与卵巢癌呈负相关，而黄酮醇（OR = 0.69）和黄酮（OR = 0.68）与肾癌呈负相关。类黄酮与前列腺癌之间没有关联。我们发现原花青素与结直肠癌之间存在负相关。聚合度较高的原花青素（≥ 10 聚体）的相关性更强（OR = 0.69）。
