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[罕见的直肠腺癌转移]

[Uncommon rectal adenocarcinoma metastases].

作者信息

Radonak J, Lakyová L, Toporcer T

机构信息

I. chirurgická klinika, Lekárska fakulta Univerzity Pavla Jozefa Safárika, Kosice, Fakultná nemocnica L. Pasteura, Kosice, Slovenská republika.

出版信息

Rozhl Chir. 2010 Aug;89(7):441-5.

PMID:20925261
Abstract

Rectal cancer treatment has become multimodal as a result of significant advances in imaging diagnostic, in surgery technique of re section and in neo and adjuvant therapy. The aim of the case report was to present a successfully treated adenocarcinoma recti and adenocarcinoma of hepatal flexurae with recidivistic metastasis and an extremely rare intergrowth of the metastasis into venous system. A 61 year old patient underwent low resection of recti according to Dixon because of well differentiated adenocarcinoma with classification T3N0M0. The patient was reoperated because of metastasis of adenocarcinoma in the abdominal wall (16 x 15 x 20 cm) after chemotherapy (FUL-5-fluorouracyl) and radiation dose of 50.4 Gy. The metastasis of abdominal wall was extirpated after another cycle of adjuvant therapy of FUL+Leukovorin. 26 months after the first operation, a new sessile polyp was found in the hepatal flexurae with histological finding of well differentiated adenocarcinoma. The patient underwent right hemicolectomy. Since lymphatic nodes were without metastasis, the patient was not indicated for chemotherapy. Two months later, the patient was admitted because of phlebothrombosis of left femoral vein. The patient underwent three reoperations with total extirpation of recidivistic tumor located in left thigh and received six cycles of Xeloda. Histological examination proved an intergrowth into great saphenous vein. Authors did not come across a case in the literature with an intergrowth of metastasis into venous system with a five year survival of a patient. The patient from this case report has no local relapse and metastasis six years after the first operation.

摘要

由于影像诊断、直肠切除手术技术以及新辅助和辅助治疗等方面取得了重大进展,直肠癌的治疗已变得多模式化。本病例报告的目的是介绍一例成功治疗的直肠腺癌和肝曲腺癌,伴有复发性转移,且转移灶极其罕见地长入静脉系统。一名61岁患者因高分化腺癌(T3N0M0)接受了Dixon法低位直肠切除术。患者在接受化疗(5-氟尿嘧啶)和50.4 Gy的放疗后,因腹壁腺癌转移(16×15×20 cm)而再次手术。在进行另一周期的5-氟尿嘧啶+亚叶酸辅助治疗后,切除了腹壁转移灶。首次手术后26个月,在肝曲发现一个新的无蒂息肉,组织学检查显示为高分化腺癌。患者接受了右半结肠切除术。由于淋巴结无转移,患者未接受化疗。两个月后,患者因左股静脉血栓形成入院。患者接受了三次再次手术,完全切除了位于左大腿的复发性肿瘤,并接受了六个周期的希罗达治疗。组织学检查证实转移灶长入大隐静脉。作者在文献中未遇到过转移灶长入静脉系统且患者存活五年的病例。本病例报告中的患者在首次手术后六年无局部复发和转移。

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