使用 Cu(I) 催化的 C-O 键形成反应进行几何分解树状大分子的收敛合成。
Convergent synthesis of geometrically disassembling dendrimers using Cu(I)-catalyzed C-O bond formation.
机构信息
The University of Arizona, Department of Chemistry and Biochemistry, 1306 East University Boulevard, Tucson, Arizona 85721, United States.
出版信息
Org Lett. 2010 Nov 5;12(21):4944-7. doi: 10.1021/ol102081q.
PMID:20925328
Abstract
The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.
摘要
基于 2,4-双(羟甲基)苯酚单元的几何可降解树状大分子的收敛合成方法。该合成方案的关键步骤涉及 CuI/3,4,7,8-四甲基-1,10-菲啰啉催化的芳基碘化物和醇的偶联反应。讨论了这些化合物的合成和分解。
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