甲状腺功能亢进或减退患者的免疫学和血液学变化。

Immunological and hematological changes in patients with hyperthyroidism or hypothyroidism.

作者信息

Jafarzadeh Abdollah, Poorgholami Masoud, Izadi Nazanin, Nemati Maryam, Rezayati Mohammad

机构信息

Department of Immunology, Rafsanjan University of Medical Sciences, Iran.

出版信息

Clin Invest Med. 2010 Oct 1;33(5):E271-9. doi: 10.25011/cim.v33i5.14352.

DOI:10.25011/cim.v33i5.14352

PMID:20926033

Abstract

AIMS

Thyroid hormones have been shown to influence the immune system and haematopoiesis. The aim of this study was to evaluate some immunological and hematological parameters in peripheral blood of hypo- or hyperthyroid women.

MATERIALS AND METHODS

Blood samples were collected from 50 women with hypothyroid disease, 50 women with hyperthyroid disease and a control group consisting of 50 sex - and age - matched euthyroid subjects. Thyroid function assesed according to measurent of T3, T4 and TSH levels. The complete blood count (CBC), total and differential counts of white blood cells (WBC), serum levels of immunoglobulins (IgG, IgA, IgM and IgE) and C3 and C4 complement components determined in three groups by using standard immunological and hematological methods.

RESULTS

In hyperthyroid women the mean serum concentrations of IgG (2312.4±584 mg/dl), IgA (296± 87 mg/dl) and IgE ( 301± 264 IU/ml) were significantly higher than those found in the control group (1539± 974 mg/dl, P < 0.0003; 234± 116 mg/dl, P < 0.01; 109.8±115 IU/ml, P < 0.0001, respectively) and the mean MCV was significantly lower in comparison with the euthyroid group (P < 0.05). Hypothyroid patients had higher serum IgE concentrations in comparison with the euthyroid group (179.8± 218 IU/ml vs. 109.8± 115 IU/ml; P < 0.047). The mean serum C3 concentration in hypothyroid patients was also significantly higher in comparison with the euthyroid group (138.7± 36.6 mg/ml vs. 117.8± 32.1 mg/dl; P < 0.01). In the hypothyroid group the mean eosinophil count was markedly higher in comparison with the hyperthyroid group (P < 0.06) and the mean count of RBC and the levels of some RBC-related indices, such as hematocrit and hemoglobin, were significantly lower in comparison with the euthyroid group (P < 0.05).

CONCLUSION

These results indicate hypergammablobulinemia and lower MVC in hyperythyroid patients, and higher IgE levels, C3 levels and eosinophil count as well as anemia in hypothyroid patients.

摘要

目的

甲状腺激素已被证明会影响免疫系统和造血功能。本研究的目的是评估甲状腺功能减退或亢进女性外周血中的一些免疫和血液学参数。

材料与方法

采集了50例甲状腺功能减退症女性、50例甲状腺功能亢进症女性的血样，以及由50名年龄和性别匹配的甲状腺功能正常受试者组成的对照组。根据T3、T4和TSH水平的测量来评估甲状腺功能。采用标准免疫和血液学方法测定三组的全血细胞计数（CBC）、白细胞总数和分类计数（WBC）、免疫球蛋白（IgG、IgA、IgM和IgE）血清水平以及C3和C4补体成分。

结果

甲状腺功能亢进女性的IgG（2312.4±584mg/dl）、IgA（296±87mg/dl）和IgE（301±264IU/ml）平均血清浓度显著高于对照组（分别为1539±974mg/dl，P<0.0003；234±116mg/dl，P<0.01；109.8±115IU/ml，P<0.0001），且平均红细胞平均体积（MCV）与甲状腺功能正常组相比显著降低（P<0.05）。甲状腺功能减退患者与甲状腺功能正常组相比，血清IgE浓度更高（179.8±218IU/ml对109.8±115IU/ml；P<0.047）。甲状腺功能减退患者的平均血清C3浓度与甲状腺功能正常组相比也显著更高（138.7±36.6mg/ml对117.8±32.1mg/dl；P<0.01）。在甲状腺功能减退组中，嗜酸性粒细胞平均计数明显高于甲状腺功能亢进组（P<0.06），红细胞平均计数以及一些与红细胞相关的指标水平，如血细胞比容和血红蛋白，与甲状腺功能正常组相比显著降低（P<0.05）。