Faculty of Life and Social Sciences, Swinburne University, Hawthorn, Victoria, Australia.
Eur J Public Health. 2012 Feb;22(1):139-44. doi: 10.1093/eurpub/ckq136. Epub 2010 Oct 5.
The success of human population biobanks are dependent on the publics' willingness to participate. This research aimed to determine those factors important in determining the public's intention to donate a biological sample to a publicly funded biobank, and allow that sample to be linked with medical records.
A national sample of 1000 Australians was surveyed via telephonic interviews. Questions included the reported likelihood that respondents would participate in biobank research, ratings of trust in biobanks, beliefs that biobank research will lead to improved health care and general ratings of comfort with blood taking and DNA analysis.
The sample reported a high level of trust in university biobanks, a strong belief that biobank research will lead to improved health care and a strong willingness to participate in biobank research. Using structural equation modelling, trust in the biobank was found to be the most important determinant of intention to participate in biobank research, followed by general comfort with blood taking and DNA analysis, belief in health-care benefits and higher education. Gender, age, parental status and experience of genetic conditions were not significantly associated with intention to participate.
Australians are generally willing to participate in biobank research, and this is strongly determined by trust. While benefit beliefs and comfort with research are also relevant, higher trust was associated with intention regardless of these factors, suggesting reasons other than concern for improved health care are important in determining the publics' willingness to participate in biobank research.
人类群体生物库的成功取决于公众参与的意愿。本研究旨在确定哪些因素对决定公众向公共资助的生物库捐赠生物样本并允许将该样本与医疗记录相关联的意愿很重要。
通过电话访谈对 1000 名澳大利亚人进行了全国性抽样调查。问题包括受访者参与生物库研究的可能性、对生物库的信任度评分、对生物库研究将导致改善医疗保健的信念以及对采血和 DNA 分析的总体舒适度。
该样本报告对大学生物库的高度信任，强烈认为生物库研究将导致改善医疗保健，并且非常愿意参与生物库研究。使用结构方程模型，发现对生物库的信任是参与生物库研究意愿的最重要决定因素，其次是对采血和 DNA 分析的一般舒适度、对医疗保健益处的信念以及高等教育。性别、年龄、父母状况和遗传状况的经验与参与意向没有显著相关。
澳大利亚人普遍愿意参与生物库研究，这主要取决于信任。虽然利益信念和对研究的舒适度也很相关，但无论这些因素如何，更高的信任度与意向相关，这表明除了改善医疗保健的关注外，其他原因在决定公众参与生物库研究的意愿方面很重要。
