Liu Wen-Kang, Jiang Xiang-Yang, Ren Jian-Kang, Zhang Zhen-Xi
Department of Clinical Laboratory Sciences, Shaanxi Provincial People's Hospital, Shannxi Province, P. R. China.
Onkologie. 2010;33(10):500-3. doi: 10.1159/000319692. Epub 2010 Sep 20.
Apoptosis-stimulating protein of p53 (ASPP) family members can stimulate the apoptotic function of p53 but have no impact on its cell cycle arrest function.
The expression pattern of the ASPP family consisting of ASPP1, ASPP2, and iASPP was examined by immunohistochemistry in 45 formalin-fixed and paraffin-embedded endometrial endometrioid adenocarcinoma (EEA) specimens and 26 normal endometrial tissue (NET) samples.
The expression rates of ASPP1 and ASPP2 in EEA were significantly lower than those in NET (p < 0.05). However, the iASPP expression rate in EEA was statistically higher in contrast to NET (p < 0.05). Expression of ASPP1 and iASPP in EEA had no correlation with any clinicopathological features (p > 0.05). iASPP was associated with grade, invasion, and lymph node metastasis (p < 0.05).
It is a novel finding that the expression pattern of the ASPP family members has respective pathological and clinical implications in EEA, and iASPP might be a candidate target for EEA therapy.
p53凋亡刺激蛋白（ASPP）家族成员可刺激p53的凋亡功能，但对其细胞周期阻滞功能无影响。
采用免疫组织化学法检测45例福尔马林固定石蜡包埋的子宫内膜样腺癌（EEA）标本和26例正常子宫内膜组织（NET）样本中由ASPP1、ASPP2和iASPP组成的ASPP家族的表达模式。
EEA中ASPP1和ASPP2的表达率显著低于NET（p<0.05）。然而，与NET相比，EEA中iASPP的表达率在统计学上更高（p<0.05）。EEA中ASPP1和iASPP的表达与任何临床病理特征均无相关性（p>0.05）。iASPP与分级、浸润及淋巴结转移相关（p<0.05）。
ASPP家族成员的表达模式在EEA中具有各自的病理和临床意义，这是一项新发现，且iASPP可能是EEA治疗的候选靶点。
