Utsalo S J, Onoyom-Ita V, Ifeanyi-Chukwu M, Akpan J O
Department of Medical Microbiology & Parasitology, University of Calabar Teaching Hospital, Nigeria.
Cent Afr J Med. 1990 Nov;36(11):278-83.
The relationship of home medication to the pathology and microbiological profiles of chronic otitis media was studied in 135 children with middle ear infections. Middle ear lesions were examined and sample obtained for microscopy and culture for bacterial and fungal pathogens. Of a total 115 patients who received home treatment, mostly with extracts of a local herb, Cleome ciliata and unprescribed antibiotics, 111 (96.5 pc) had chronic otitis media with purulent effusion (OME), compared with 11 (55 pc) otitis media (OM) cases among 20 patients who had not received such treatments (p less than 0.05). Staphylococcus aureus and Pseudomonas spp. were the predominant isolates; the latter were the sole infecting agents in 41 episodes and occurred in 10 co-infections. Sensitivity pattern of bacterial isolates indicated that a large proportion of infections would respond to empiric treatment with gentamicin in anticipation of laboratory results on sensitivity tests. This report suggests further studies to define the significance of these medications in the pathogenesis of chronic OME in Nigerian children.
对135名患有中耳感染的儿童进行了研究，以探讨家庭用药与慢性中耳炎的病理学及微生物学特征之间的关系。对中耳病变进行了检查，并采集样本进行显微镜检查及细菌和真菌病原体培养。在总共115名接受家庭治疗的患者中，大多数使用当地一种草药刺果瓜的提取物和未开具处方的抗生素，其中111例（96.5%）患有慢性化脓性中耳炎（OME），相比之下，在20名未接受此类治疗的患者中，有11例（55%）患有中耳炎（OM）（p<0.05）。金黄色葡萄球菌和假单胞菌属是主要的分离菌株；后者在41次感染中为唯一感染病原体，且发生在10次合并感染中。细菌分离株的药敏模式表明，在等待敏感性试验实验室结果期间，很大一部分感染对庆大霉素经验性治疗有反应。本报告建议进一步开展研究，以明确这些药物在尼日利亚儿童慢性OME发病机制中的意义。
