Bozhkov Anatoliy, Padalko Vladimir, Dlubovskaya Viktoria, Menzianova Natalia
Research Institute of Biology, V N Karazin Kharkov National University, Kharkov 61077, Ukraine.
Indian J Exp Biol. 2010 Jul;48(7):679-96.
The rate of changes of heavy metal ions concentrations in the organism or biological system will determine the choice of strategy of realization of heavy metal ions effect and, consequently, the biological effect itself. Which of the possible strategies will dominate, depend on the rate of changes of concentration of heavy metal ions in biological systems, functional activity of organism at the moment of metal action and on metals chemical properties. Keeping this view, the present review deals with the concept of time-based alterations of concentration of heavy metal ions (TACMI) in biological systems. On the basis of TACMI concept formation of organism resistance to metal ions action could be explained. In the event of slow increase of its concentration in organism, it produces induction of metallothioneins, other stress-proteins and relative changes in the whole metabolic system. This, first of all, results in formation of new specific epigenotypes, which provide higher resistance (hormesis effect) not only to metal ions that induced this effect, but also to such stress-factors as high temperature (at least, for micro-algae cells).
生物机体或生物系统中重金属离子浓度的变化速率将决定实现重金属离子效应的策略选择，进而决定生物效应本身。哪种可能的策略占主导地位，取决于生物系统中重金属离子浓度的变化速率、金属作用时刻机体的功能活性以及金属的化学性质。基于此观点，本综述探讨了生物系统中重金属离子浓度随时间变化（TACMI）的概念。基于TACMI概念，可以解释机体对金属离子作用产生抗性的形成过程。当生物机体内其浓度缓慢增加时，会诱导金属硫蛋白、其他应激蛋白的产生以及整个代谢系统的相关变化。这首先导致形成新的特定表观基因型，其不仅能提供对诱导此效应的金属离子的更高抗性（兴奋效应），还能提供对诸如高温（至少对于微藻细胞而言）等应激因素的更高抗性。
