Department of Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Leuk Lymphoma. 2010 Nov;51(11):2039-46. doi: 10.3109/10428194.2010.520049. Epub 2010 Oct 7.
By reviewing 3725 lymphomas diagnosed in our institution from 1999 to 2010, we found eight cases (0.21%) of primary lymphoma in soft tissue with comprehensive histologic and immunohistochemical studies. Of the eight cases of primary lymphoma in soft tissue, two patients were male and six were female. The mean age was 54.8 years with range from 23 to 76 years. The greatest diameter of tumor ranged from 1.3 to 20 cm with an average diameter of 7.5 cm. Six cases were diffuse large B-cell lymphoma (DLBCL), subclassified as three DLBCL non-germinal center B-cell phenotype, one DLBCL germinal center B-cell phenotype, and two (Epstein-Barr Virus) EBV-positive DLBCL of the elderly; one case was anaplastic large cell lymphoma, ALK-positive; and one case was peripheral T cell lymphoma, not otherwise specified. Follow-up was available for four patients. One patient who refused further therapy died of the disease at 2 months after diagnosis. The other three patients with follow-up were alive without recurrence and metastatic disease at 9, 36, and 48 months, respectively, after excisional biopsy combined with appropriate chemotherapy and/or radiation therapy.
通过对我院 1999 年至 2010 年诊断的 3725 例淋巴瘤进行回顾性分析，我们发现 8 例（0.21%）原发性软组织淋巴瘤，这些患者均经全面的组织学和免疫组织化学研究。8 例原发性软组织淋巴瘤中，男性 2 例，女性 6 例，平均年龄 54.8 岁，范围 23-76 岁。肿瘤最大直径 1.3-20cm，平均直径 7.5cm。6 例为弥漫性大 B 细胞淋巴瘤（DLBCL），亚类包括 3 例非生发中心 B 细胞表型的 DLBCL、1 例生发中心 B 细胞表型的 DLBCL 和 2 例（EB 病毒）EBV 阳性的老年 DLBCL；1 例为间变大细胞淋巴瘤，ALK 阳性；1 例为外周 T 细胞淋巴瘤，非特指型。4 例患者可进行随访。1 例患者因拒绝进一步治疗，于诊断后 2 个月死于疾病。3 例有随访的患者分别在接受肿瘤切除联合适当的化疗和/或放疗后 9、36 和 48 个月时仍无复发和转移。
