Department of Hematology, Juntendo University Shizuoka Hospital, Japan.
Department of Hematology, Juntendo University Urayasu Hospital, Japan.
Intern Med. 2021 Oct 15;60(20):3309-3315. doi: 10.2169/internalmedicine.7391-21. Epub 2021 May 7.
Primary skeletal muscle lymphoma is extremely uncommon, and there have only been eight previous case reports on primary skeletal muscle peripheral T-cell lymphoma, not otherwise specified (PSM-PTCL, NOS). We herein report an autopsy case of a 71-year-old woman with PSM-PTCL, NOS, who had a 24-year history of systemic sclerosis treated with immunosuppressive drugs. A post-mortem examination revealed infiltration of lymphoma cells positive for T-cell markers, cytotoxic markers, and p53. This case was considered to be one of other iatrogenic immunodeficiency-associated lymphoproliferative disorder (OIIA-LPD). This is the first case categorized under both PSM-PTCL, NOS, and OIIA-LPD.
原发性骨骼肌淋巴瘤极为罕见，既往仅有 8 例关于非特指性原发性骨骼肌周围 T 细胞淋巴瘤（PSM-PTCL，NOS）的病例报告。本文报告了一例 71 岁女性 PSM-PTCL，NOS 的尸检病例，该患者患有系统性硬化症，24 年来一直接受免疫抑制药物治疗。尸检显示淋巴瘤细胞浸润，T 细胞标志物、细胞毒性标志物和 p53 阳性。该病例被认为是医源性免疫缺陷相关淋巴组织增生性疾病（OIIA-LPD）之一。这是首例同时归类于 PSM-PTCL，NOS 和 OIIA-LPD 的病例。
