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原发性骨骼肌周围 T 细胞淋巴瘤:尸检病例报告及文献复习。

Primary Skeletal Muscle Peripheral T-cell Lymphoma: An Autopsy Case Report and Review of the Literature.

机构信息

Department of Hematology, Juntendo University Shizuoka Hospital, Japan.

Department of Hematology, Juntendo University Urayasu Hospital, Japan.

出版信息

Intern Med. 2021 Oct 15;60(20):3309-3315. doi: 10.2169/internalmedicine.7391-21. Epub 2021 May 7.

Abstract

Primary skeletal muscle lymphoma is extremely uncommon, and there have only been eight previous case reports on primary skeletal muscle peripheral T-cell lymphoma, not otherwise specified (PSM-PTCL, NOS). We herein report an autopsy case of a 71-year-old woman with PSM-PTCL, NOS, who had a 24-year history of systemic sclerosis treated with immunosuppressive drugs. A post-mortem examination revealed infiltration of lymphoma cells positive for T-cell markers, cytotoxic markers, and p53. This case was considered to be one of other iatrogenic immunodeficiency-associated lymphoproliferative disorder (OIIA-LPD). This is the first case categorized under both PSM-PTCL, NOS, and OIIA-LPD.

摘要

原发性骨骼肌淋巴瘤极为罕见,既往仅有 8 例关于非特指性原发性骨骼肌周围 T 细胞淋巴瘤(PSM-PTCL,NOS)的病例报告。本文报告了一例 71 岁女性 PSM-PTCL,NOS 的尸检病例,该患者患有系统性硬化症,24 年来一直接受免疫抑制药物治疗。尸检显示淋巴瘤细胞浸润,T 细胞标志物、细胞毒性标志物和 p53 阳性。该病例被认为是医源性免疫缺陷相关淋巴组织增生性疾病(OIIA-LPD)之一。这是首例同时归类于 PSM-PTCL,NOS 和 OIIA-LPD 的病例。

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